Simple Summary Fanconi anemia (FA) is a genetic disorder that is characterized by bone
marrow failure (BMF), developmental abnormalities, and predisposition to cancer. In this …

With the advent of precision genomics, hereditary predisposition to hematopoietic
neoplasms—collectively known as hereditary predisposition syndromes (HPS)—are being …

The interaction of germline variation and somatic cancer driver mutations is under-
investigated. Here we describe the genomic mitochondrial landscape in adult acute myeloid …

Familial ovarian cancer (OC) cases not harbouring pathogenic variants in either of the
BRCA1 and BRCA2 OC-predisposing genes, which function in homologous recombination …

Activation of the Fanconi anemia (FA) pathway after treatment with mitomycin C (MMC) is
essential for preventing chromosome translocations termed" radials." When replication forks …

Leukemia is a lethal cancer in which white blood cells undergo proliferation and immature
white blood cells are seen in the bloodstream. Without diagnosis and management in early …

The development of breast cancer depends on several risk factors, including environmental,
lifestyle and genetic factors. Despite the evolution of DNA sequencing techniques and …

DNA-crosslinks are one of the most severe types of DNA lesions. Crosslinks (CLs) can be
subdivided into DNA-intrastrand CLs, DNA-interstrand CLs (ICLs) and DNA-protein …

BRCA2 (also known as FANCD1) is a core component of the Fanconi pathway and
suppresses transformation of immature T-cells in mice. However, the contribution of Fanconi …

Fanconi anemia (FA) is the most common inherited bone marrow failure syndrome,
characterized by cellular DNA repair deficiency, developmental defects, and a 700-fold …