Severe durable changes may occur to the DNA structure caused by exogenous and
endogenous risk factors initiating the process of carcinogenesis. By evidence, a large …

Cancer cells frequently develop resistance to chemotherapeutic therapies and targeted
drugs, which has been a significant challenge in cancer management. With the growing …

Covering: 2008 to 2018 This review provides a comprehensive overview of newly
discovered natural products containing a tropolonoid motif covering 2008 up to 2018 and …

Resistance to current cancer treatments is an important problem that arises through various
mechanisms, but one that stands out involves an overexpression of several factors …

Tropolones are promising organic compounds that can have important biologic effects. We
developed a series of new 2-quinolyl-1, 3-tropolones derivatives that were prepared by the …

Chalcomoracin (CMR) is a kind of Diels–Alder adduct extracted from the mulberry leaves.
Recent studies showed that CMR has a broad spectrum of anticancer activities and induces …

Background Resistance to radiotherapy is a common cause of treatment failure in advanced
head and neck squamous cell carcinoma (HNSCC). ß-Thujaplicin, a natural tropolone …

Aims: Intrahepatic cholangiocarcinoma (ICC) is a highly malignant and heterogeneous
cancer with a poor prognosis. At present, there is no optimal treatment except for surgical …

В обзоре приведены сведения о механизмах противоопухолевого действия природных
и синтетических соединений трополонового ряда, полученные в течение последних 30 …

Results Fanconi anemia (FA), breast, and ovarian cancers are predisposed to by mutations
in the BRCA2 (BReast CAncer gene 2) recombination gene. Homologous recombination …