Pan-genomics in the human genome era

RM Sherman, SL Salzberg - Nature Reviews Genetics, 2020 - nature.com
Since the early days of the genome era, the scientific community has relied on a single
'reference'genome for each species, which is used as the basis for a wide range of genetic …

Helicobacter pylori treatment in the post-antibiotics era—searching for new drug targets

P Roszczenko-Jasińska, MI Wojtyś… - Applied Microbiology …, 2020 - Springer
Helicobacter pylori, a member of Epsilonproteobacteria, is a Gram-negative microaerophilic
bacterium that colonizes gastric mucosa of about 50% of the human population. Although …

Identification of putative vaccine candidates against Helicobacter pylori exploiting exoproteome and secretome: a reverse vaccinology based approach

A Naz, FM Awan, A Obaid, SA Muhammad… - Infection, Genetics and …, 2015 - Elsevier
Helicobacter pylori (H. pylori) is an important pathogen associated with diverse gastric
disorders ranging from peptic ulcer to malignancy. It has also been recognized by the World …

Vaccinomics to Design a Multi-Epitopes Vaccine for Acinetobacter baumannii

M Ud-Din, A Albutti, A Ullah, S Ismail, S Ahmad… - International Journal of …, 2022 - mdpi.com
Antibiotic resistance (AR) is the result of microbes' natural evolution to withstand the action
of antibiotics used against them. AR is rising to a high level across the globe, and novel …

Towards A Novel Multi-Epitopes Chimeric Vaccine for Simulating Strong Immune Responses and Protection against Morganella morganii

A Ullah, S Ahmad, S Ismail, Z Afsheen… - International Journal of …, 2021 - mdpi.com
Morganella morganii is one of the main etiological agents of hospital-acquired infections
and no licensed vaccine is available against the pathogen. Herein, we designed a multi …

Pangenome and immuno-proteomics analysis of Acinetobacter baumannii strains revealed the core peptide vaccine targets

A Hassan, A Naz, A Obaid, RZ Paracha, K Naz… - BMC genomics, 2016 - Springer
Background Acinetobacter baumannii has emerged as a significant nosocomial pathogen
during the last few years, exhibiting resistance to almost all major classes of antibiotics …

Pan-genome analysis of oral bacterial pathogens to predict a potential novel multi-epitopes vaccine candidate

T Rida, S Ahmad, A Ullah, S Ismail… - International Journal of …, 2022 - mdpi.com
Porphyromonas gingivalis is a Gram-negative anaerobic bacterium, mainly present in the
oral cavity and causes periodontal infections. Currently, no licensed vaccine is available …

Computer-Aided Multi-Epitope Vaccine Design against Enterobacter xiangfangensis

A Alshammari, M Alharbi, A Alghamdi… - International Journal of …, 2022 - mdpi.com
Antibiotic resistance is a global public health threat and is associated with high mortality due
to antibiotics' inability to treat bacterial infections. Enterobacter xiangfangensis is an …

Vaccinomics to design a novel single chimeric subunit vaccine for broad-spectrum immunological applications targeting nosocomial Enterobacteriaceae pathogens

S Ismail, S Ahmad, SS Azam - European Journal of Pharmaceutical …, 2020 - Elsevier
Healthcare associated infections (HAIs) are major cause of elevated mortality, morbidity, and
high healthcare costs. Development of a vaccine targeting these pathogens could benefit in …

Whole Genome Sequence and Phylogenetic Analysis Show Helicobacter pylori Strains from Latin America Have Followed a Unique Evolution Pathway

ZY Munoz-Ramirez, A Mendez-Tenorio… - Frontiers in cellular …, 2017 - frontiersin.org
Helicobacter pylori (HP) genetics may determine its clinical outcomes. Despite high
prevalence of HP infection in Latin America (LA), there have been no phylogenetic studies in …