IgE not only provides protective immunity against helminth parasites but can also mediate
the type I hypersensitivity reactions that contribute to the pathogenesis of allergic diseases …

Allergic asthma and allergic rhinitis/conjunctivitis are characterized by a TH2-dominated
immune response associated with increased serum IgE levels in response to inhaled …

The diversity of circulating human B cells is unknown. We use single-cell RNA sequencing
(RNA-seq) to examine the diversity of both antigen-specific and total B cells in healthy …

The spatial distribution of lymphocyte clones within tissues is critical to their development,
selection, and expansion. We have developed spatial transcriptomics of variable, diversity …

B1 cells differ in many ways from conventional B cells, most prominently in the production of
natural immunoglobulin, which is vitally important for protection against pathogens. B1 cells …

Immunoglobulin E (IgE) antibodies protect against helminth infections but can also cause life-
threatening allergic reactions. Despite their role in human health, the cells that produce …

Recent studies have shown that persistent specific antibody titer is provided by long-lived
plasma cells (PC) which constitute a new kind of'memory-providing cells'. In the present …

IgE-mediated allergy is a hypersensitivity disease affecting more than 25% of the population.
The structures of the most common allergens have been revealed through molecular cloning …

Human immunodeficiency virus (HIV) infection leads to numerous perturbations of B cells
through mechanisms that remain elusive. We performed DNA microarray, phenotypic, and …

The long-term effectiveness of antibody responses relies on the development of humoral
immune memory. Humoral immunity is maintained by long-lived plasma cells that secrete …