Molecular typing has revolutionized epidemiological studies of infectious diseases,
including those of a mycobacterial etiology. With the advent of fingerprinting techniques …

Background Pyrazinamide (PZA) is crucial for tuberculosis (TB) treatment, given its unique
ability to eradicate persister bacilli. The worldwide burden of PZA resistance remains poorly …

Tuberculosis continues to be a global health threat. Pyrazinamide (PZA) is an important first-
line drug in multidrug-resistant tuberculosis treatment. The emergence of strains resistant to …

Standard culture-based testing of the susceptibility of Mycobacterium tuberculosis to
pyrazinamide is difficult to perform. This systematic review with meta-analyses evaluated the …

Pyrazinamide (PZA) is an important first-line drug in the treatment of tuberculosis (TB) and of
significant interest to the HIV-infected community due to the prevalence of TB-HIV …

Introduction The clinical practicability of DNA microarray chip in detecting the presence of
mycobacterial species/isolates directly in the skin tissues has not been evaluated, nor the …

SETTING: Pyrazinamide (PZA), an important first-line drug for anti-tuberculosis treatment,
demonstrates potent activity against semi-dormant bacilli in acidic environments. However …

Genetics-based drug susceptibility testing has improved the diagnosis of drug-resistant
tuberculosis but is limited by our lack of knowledge of all resistance mechanisms. Next …

It has been widely accepted, that pyrazinamide (PZA) resistance in Mycobacterium
tuberculosis is correlated with mutations in the pncA gene. But since years researchers have …

Nicotinamidase/pyrazinamidase (PncA) is involved in the NAD+ salvage pathway of
Mycobacterium tuberculosis and other bacteria. In addition to hydrolyzing nicotinamide into …