Abstract Interleukin 6 (IL-6) has a broad effect on cells of the immune system and those not
of the immune system and often displays hormone-like characteristics that affect homeostatic …

Cancers | Free Full-Text | Obesity-Induced TNFα and IL-6 Signaling: The Missing Link between
Obesity and Inflammation—Driven Liver and Colorectal Cancers Next Article in Journal Effects …

The successful treatment of certain autoimmune conditions with the humanized anti–IL-6
receptor (IL-6R) antibody tocilizumab has emphasized the clinical importance of cytokines …

Interleukin 6 (IL-6), which was originally identified as a B-cell differentiation factor, is now
known to be a multifunctional cytokine that regulates the immune response, hematopoiesis …

Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disorder. The study of
diverse mouse models of lupus has provided clues to the etiology of SLE. Spontaneous …

Environmental agents have been gaining more attention in recent years for their role in the
pathogenesis of autoimmune diseases (ADs). Increasing evidence has linked environmental …

Rheumatoid arthritis is a common and debilitating autoimmune disease whose cause and
mechanism remain a mystery. We recently described a T cell receptor transgenic mouse …

Tetramethylpentadecane (TMPD, or commonly known as pristane)-induced lupus is a
murine model of systemic lupus erythematosus (SLE). Renal disease and autoantibody …

Detection of and response to microbial infections by the immune system depends largely on
a family of pattern-recognition receptors called Toll-like receptors (TLRs). These receptors …

Work in recent years has shown an essential role for Toll-like receptors (TLRs) in the
activation of innate and adaptive immunity in vertebrate animals. These germ-line encoded …