DNA replication is central to cell proliferation. Studies in the past six decades since the
proposal of a semiconservative mode of DNA replication have confirmed the high degree of …

Cellular DNA replication is initiated through the action of multiprotein complexes that
recognize replication start sites in the chromosome (termed origins) and facilitate duplex …

Canonical non-homologous end joining (c-NHEJ) repairs DNA double-strand breaks (DSBs)
in G1 cells with biphasic kinetics. We show that DSBs repaired with slow kinetics, including …

Cul4 E3 ubiquitin ligases contain the cullin 4 scaffold and the triple β propeller Ddb1 adaptor
protein, but few substrate receptors have been identified. Here, we identify 18 Ddb1-and …

To ensure its duplication, chromosomal DNA must be precisely duplicated in each cell cycle,
with no sections left unreplicated, and no sections replicated more than once. Eukaryotic …

DNA replication is tightly controlled in eukaryotic cells to ensure that an exact copy of the
genetic material is inherited by both daughter cells. Oscillating waves of cyclin-dependent …

The ability of cells to make exact replicas of themselves is central to the life and
development of complex organisms. Initial insights into the question of how cells divide …

In eukaryotic cells, prereplication complexes (pre-RCs) are assembled on chromatin in the
G1 phase, rendering origins of DNA replication competent to initiate DNA synthesis. When …

Replication licensing is carefully regulated to restrict replication to once in a cell cycle. In
higher eukaryotes, regulation of the licensing factor Cdt1 by proteolysis and Geminin is …

One of the fundamental challenges facing the cell is to accurately copy its genetic material to
daughter cells. When this process goes awry, genomic instability ensues in which genetic …