[HTML][HTML] Diabetic macular edema: current understanding, molecular mechanisms and therapeutic implications

J Zhang, J Zhang, C Zhang, J Zhang, L Gu, D Luo… - Cells, 2022 - mdpi.com
Diabetic retinopathy (DR), with increasing incidence, is the major cause of vision loss and
blindness worldwide in working-age adults. Diabetic macular edema (DME) remains the …

Photoreceptor cells and RPE contribute to the development of diabetic retinopathy

D Tonade, TS Kern - Progress in retinal and eye research, 2021 - Elsevier
Diabetic retinopathy (DR) is a leading cause of blindness. It has long been regarded as
vascular disease, but work in the past years has shown abnormalities also in the neural …

Endothelial dysfunction and diabetes: effects on angiogenesis, vascular remodeling, and wound healing

GK Kolluru, SC Bir, CG Kevil - International journal of vascular …, 2012 - Wiley Online Library
Diabetes mellitus (DM) is a chronic metabolic disorder characterized by inappropriate
hyperglycemia due to lack of or resistance to insulin. Patients with DM are frequently afflicted …

Diabetic retinopathy, a vascular and inflammatory disease: therapeutic implications

F Semeraro, F Morescalchi, A Cancarini, A Russo… - Diabetes & …, 2019 - Elsevier
Diabetic retinopathy (DR) is the most common microvascular complication of diabetes and
the leading cause of visual impairment in the working-age population in the Western world …

[HTML][HTML] Age-related macular degeneration: role of oxidative stress and blood vessels

Y Ruan, S Jiang, A Gericke - International journal of molecular sciences, 2021 - mdpi.com
Age-related macular degeneration (AMD) is a common irreversible ocular disease
characterized by vision impairment among older people. Many risk factors are related to …

Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina

Y Du, A Veenstra, K Palczewski… - Proceedings of the …, 2013 - National Acad Sciences
Accumulating evidence suggests that photoreceptor cells play a previously unappreciated
role in the development of early stages of diabetic retinopathy, but the mechanism by which …

[HTML][HTML] Oxidative stress and vascular dysfunction in the retina: Therapeutic strategies

Y Ruan, S Jiang, A Musayeva, A Gericke - Antioxidants, 2020 - mdpi.com
Many retinal diseases, such as diabetic retinopathy, glaucoma, and age-related macular
(AMD) degeneration, are associated with elevated reactive oxygen species (ROS) levels …

Oxidative stress and reactive oxygen species: a review of their role in ocular disease

L Ung, U Pattamatta, N Carnt… - Clinical …, 2017 - portlandpress.com
For many years, oxidative stress arising from the ubiquitous production of reactive oxygen
species (ROS) has been implicated in the pathogenesis of various eye diseases. While …

Diabetic retinopathy: loss of neuroretinal adaptation to the diabetic metabolic environment

SF Abcouwer, TW Gardner - Annals of the New York Academy …, 2014 - Wiley Online Library
Diabetic retinopathy (DR) impairs vision of patients with type 1 and type 2 diabetes,
associated with vascular dysfunction and occlusion, retinal edema, hemorrhage, and …

[HTML][HTML] Diabetes and retinal vascular dysfunction

ES Shin, CM Sorenson, N Sheibani - Journal of ophthalmic & …, 2014 - ncbi.nlm.nih.gov
Diabetes predominantly affects the microvascular circulation of the retina resulting in a
range of structural changes unique to this tissue. These changes ultimately lead to altered …