Significant progress has been made in the field of cartilage and bone tissue engineering
over the last two decades. As a result, there is real promise that strategies to regenerate …

Stem cell behaviors are regulated by multiple microenvironmental cues. As an external
signal, mechanical stiffness of the extracellular matrix is capable of governing stem cell fate …

Cartilage is a dense connective tissue with limited self-repair capabilities. Mesenchymal
stem cell (MSC) laden hydrogels are commonly used for fibrocartilage and articular cartilage …

Osteoarthritis (OA) is a degenerative disease that affects various tissues surrounding joints
such as articular cartilage, subchondral bone, synovial membrane, and ligaments. No …

Chondrocytes in articular cartilage are surrounded by a narrow pericellular matrix (PCM)
that is both biochemically and biomechanically distinct from the extracellular matrix (ECM) of …

Stem cells have shown substantial promise for various diseases in preclinical and clinical
trials. However, low cell engraftment rates significantly limit the clinical translation of stem …

Biophysical cues play a key role in directing the lineage commitment of mesenchymal stem
cells or multipotent stromal cells (MSC s), but the mechanotransductive mechanisms at play …

Stem cell fate has been linked to the mechanical properties of their underlying substrate,
affecting mechanoreceptors and ultimately leading to downstream biological response …

Bone organoids, which simulate and construct special organs in vitro with complex
biological functions based on tissue engineering technology, provide dramatically realistic …

Bone healing is a complicated process of tissue regeneration that is influenced by multiple
biological and biomechanical processes. In a minority of cases, these physiological …