Aerobic living is thought to generate reactive oxygen species (ROS), which are an inevitable
chemical component. They are produced exclusively in cellular compartments in aerobic …

Pseudomonas aeruginosa is an opportunistic pathogen and the leading cause of mortality
among immunocompromised patients in clinical setups. The hallmarks of virulence in P …

Organisms evolve in response to their natural environment. Consideration of natural
ecological parameters are thus of key importance for our understanding of an organism's …

Numerous bacteria utilize molecular communication systems referred to as quorum sensing
(QS) to synchronize the expression of certain genes regulating, among other aspects, the …

Pyocyanin has recently emerged as an important virulence factor produced by
Pseudomonas aeruginosa. The redox-active tricyclic zwitterion has been shown to have a …

Hosts and bacteria have coevolved over millions of years, during which pathogenic bacteria
have modified their virulence mechanisms to adapt to host defense systems. Although the …

Quorum sensing is a chemical communication process that bacteria use to regulate
collective behaviors. Disabling quorum-sensing circuits with small molecules has been …

Cell-to-cell communication is a major process that allows bacteria to sense and coordinately
react to the fluctuating conditions of the surrounding environment. In several pathogens, this …

Argonaute (AGO) proteins associate with small RNAs to direct their effector function on
complementary transcripts. The nematode Caenorhabditis elegans contains an expanded …

Pseudomonas aeruginosa is a Gram-negative γ-Proteobacterium which is known for its
capacity to colonize various niches, including some invertebrate and vertebrate hosts …