BACKGROUND Members of the cysteine-rich secretory proteins (CRISPS), antigen 5 (Ag5)
and pathogenesis-related 1 (Pr-1)(CAP) superfamily of proteins are found across the …

Purpose: An underlying cause of osteoarthritis (OA) is the inability of chondrocytes to
maintain homeostasis in response to changing stress conditions. The purpose of this article …

Back and neck pain are significant healthcare burdens that are commonly associated with
pathologies of the intervertebral disc (IVD). The poor understanding of the cellular …

Light underneath Antarctic sea‐ice is below detectable limits for up to 4 months of the year.
The ability of Antarctic sea‐ice diatoms to survive this prolonged darkness relies on their …

Background Atlantic salmon production in Tasmania (Southern Australia) occurs near the
upper limits of the species thermal tolerance. Summer water temperatures can average over …

Key points While several studies have investigated the effects of exercise training in human
skeletal muscle and the chronic effect of β2‐agonist treatment in rodent muscle, their effects …

Mechanical damage at the time of joint injury and the ensuing inflammatory response
associated with elevated levels of pro-inflammatory cytokines in the synovial fluid, are …

The Hippo pathway directs cell differentiation during organogenesis, in part by restricting
proliferation. How Hippo signaling maintains a proliferation-differentiation balance in …

Perlecan is a critical proteoglycan found in the extracellular matrix (ECM) of cartilage. In
healthy cartilage, perlecan regulates cartilage biomechanics and we previously …

CRELD2, a member of the cysteine-rich epidermal growth factor-like domain (CRELD)
protein family, is both an endoplasmic reticulum (ER)-resident protein and a secretory factor …