To PEGylate or not to PEGylate: Immunological properties of nanomedicine's most popular component, polyethylene glycol and its alternatives
Polyethylene glycol or PEG has a long history of use in medicine. Many conventional
formulations utilize PEG as either an active ingredient or an excipient. PEG found its use in …
formulations utilize PEG as either an active ingredient or an excipient. PEG found its use in …
Translational applications of hydrogels
Advances in hydrogel technology have unlocked unique and valuable capabilities that are
being applied to a diverse set of translational applications. Hydrogels perform functions …
being applied to a diverse set of translational applications. Hydrogels perform functions …
Trends in peptide drug discovery
Since the introduction of insulin almost a century ago, more than 80 peptide drugs have
reached the market for a wide range of diseases, including diabetes, cancer, osteoporosis …
reached the market for a wide range of diseases, including diabetes, cancer, osteoporosis …
Polyethylene glycol (PEG): The nature, immunogenicity, and role in the hypersensitivity of PEGylated products
Polyethylene glycol (PEG) is a versatile polymer that is widely used as an additive in foods
and cosmetics, and as a carrier in PEGylated therapeutics. Even though PEG is thought to …
and cosmetics, and as a carrier in PEGylated therapeutics. Even though PEG is thought to …
In situ PEGylation of CAR T cells alleviates cytokine release syndrome and neurotoxicity
Chimeric antigen receptor T (CAR T) cell immunotherapy is successful at treating many
cancers. However, it often induces life-threatening cytokine release syndrome (CRS) and …
cancers. However, it often induces life-threatening cytokine release syndrome (CRS) and …
[HTML][HTML] Macrophage cell membrane-based nanoparticles: a new promising biomimetic platform for targeted delivery and treatment
Y Wu, S Wan, S Yang, H Hu, C Zhang, J Lai… - Journal of …, 2022 - Springer
Synthetic nanoparticles with surface bioconjugation are promising platforms for targeted
therapy, but their simple biological functionalization is still a challenging task against the …
therapy, but their simple biological functionalization is still a challenging task against the …
Designing hydrogels for controlled drug delivery
Hydrogel delivery systems can leverage therapeutically beneficial outcomes of drug delivery
and have found clinical use. Hydrogels can provide spatial and temporal control over the …
and have found clinical use. Hydrogels can provide spatial and temporal control over the …
Engineering Single‐Atom Nanozymes for Catalytic Biomedical Applications
Nanomaterials with enzyme‐mimicking properties, coined as nanozymes, are a promising
alternative to natural enzymes owing to their remarkable advantages, such as high stability …
alternative to natural enzymes owing to their remarkable advantages, such as high stability …
Engineering poly (ethylene glycol) nanoparticles for accelerated blood clearance inhibition and targeted drug delivery
Surface modification with poly (ethylene glycol)(PEGylation) is an effective strategy to
improve the colloidal stability of nanoparticles (NPs) and is often used to minimize cellular …
improve the colloidal stability of nanoparticles (NPs) and is often used to minimize cellular …
Polyethylene glycol (PEG): a versatile polymer for pharmaceutical applications
AA D'souza, R Shegokar - Expert opinion on drug delivery, 2016 - Taylor & Francis
Introduction: Polyethylene glycol (PEG) is a polymer of choice in drug delivery systems. This
USFDA-approved polymer is popular due to its tunable properties and well-established …
USFDA-approved polymer is popular due to its tunable properties and well-established …