To PEGylate or not to PEGylate: Immunological properties of nanomedicine's most popular component, polyethylene glycol and its alternatives

D Shi, D Beasock, A Fessler, J Szebeni… - Advanced drug delivery …, 2022 - Elsevier
Polyethylene glycol or PEG has a long history of use in medicine. Many conventional
formulations utilize PEG as either an active ingredient or an excipient. PEG found its use in …

Translational applications of hydrogels

S Correa, AK Grosskopf, H Lopez Hernandez… - Chemical …, 2021 - ACS Publications
Advances in hydrogel technology have unlocked unique and valuable capabilities that are
being applied to a diverse set of translational applications. Hydrogels perform functions …

Trends in peptide drug discovery

M Muttenthaler, GF King, DJ Adams… - Nature reviews Drug …, 2021 - nature.com
Since the introduction of insulin almost a century ago, more than 80 peptide drugs have
reached the market for a wide range of diseases, including diabetes, cancer, osteoporosis …

Polyethylene glycol (PEG): The nature, immunogenicity, and role in the hypersensitivity of PEGylated products

M Ibrahim, E Ramadan, NE Elsadek, SE Emam… - Journal of Controlled …, 2022 - Elsevier
Polyethylene glycol (PEG) is a versatile polymer that is widely used as an additive in foods
and cosmetics, and as a carrier in PEGylated therapeutics. Even though PEG is thought to …

In situ PEGylation of CAR T cells alleviates cytokine release syndrome and neurotoxicity

N Gong, X Han, L Xue, R El-Mayta, AE Metzloff… - Nature Materials, 2023 - nature.com
Chimeric antigen receptor T (CAR T) cell immunotherapy is successful at treating many
cancers. However, it often induces life-threatening cytokine release syndrome (CRS) and …

[HTML][HTML] Macrophage cell membrane-based nanoparticles: a new promising biomimetic platform for targeted delivery and treatment

Y Wu, S Wan, S Yang, H Hu, C Zhang, J Lai… - Journal of …, 2022 - Springer
Synthetic nanoparticles with surface bioconjugation are promising platforms for targeted
therapy, but their simple biological functionalization is still a challenging task against the …

Designing hydrogels for controlled drug delivery

J Li, DJ Mooney - Nature Reviews Materials, 2016 - nature.com
Hydrogel delivery systems can leverage therapeutically beneficial outcomes of drug delivery
and have found clinical use. Hydrogels can provide spatial and temporal control over the …

Engineering Single‐Atom Nanozymes for Catalytic Biomedical Applications

Y Zhu, Y Liao, J Zou, J Cheng, Y Pan, L Lin, X Chen - Small, 2023 - Wiley Online Library
Nanomaterials with enzyme‐mimicking properties, coined as nanozymes, are a promising
alternative to natural enzymes owing to their remarkable advantages, such as high stability …

Engineering poly (ethylene glycol) nanoparticles for accelerated blood clearance inhibition and targeted drug delivery

Y Tian, Z Gao, N Wang, M Hu, Y Ju, Q Li… - Journal of the …, 2022 - ACS Publications
Surface modification with poly (ethylene glycol)(PEGylation) is an effective strategy to
improve the colloidal stability of nanoparticles (NPs) and is often used to minimize cellular …

Polyethylene glycol (PEG): a versatile polymer for pharmaceutical applications

AA D'souza, R Shegokar - Expert opinion on drug delivery, 2016 - Taylor & Francis
Introduction: Polyethylene glycol (PEG) is a polymer of choice in drug delivery systems. This
USFDA-approved polymer is popular due to its tunable properties and well-established …