Cyclic AMP (cAMP) plays a key regulatory role in most types of cells; however, the pathways
controlled by cAMP may present important differences between organisms and between …

Kinetoplastids, including the human pathogens Trypanosoma brucei, Trypanosoma cruzi
and Leishmania, are the only known organisms that do not regulate the transcription of …

Cyclic nucleotide specific phosphodiesterases (PDEs) are pivotal regulators of cellular
signaling. They are also important drug targets. Besides catalytic activity and substrate …

The establishment of a Gordon Research Conference devoted to cyclic nucleotide
phosphodiesterases has had an enormous impact on the field by facilitating collaborations …

N-terminal tandem GAF domains are present in 5 out of 11 mammalian phosphodiesterase
(PDE) families. The ligand for the GAF domains of PDEs 2, 5, and 6 is cGMP, whereas those …

The cGMP-binding cGMP-specific phosphodiesterase (PDE5) contains a catalytic domain
that hydrolyzes cGMP and a regulatory (R) domain that contains two GAFs (a and b; GAF is …

Kinetoplastids are unicellular, eukaryotic, flagellated protozoans containing the eponymous
kinetoplast. Within this order, the family of trypanosomatids are responsible for some of the …

One of the most promising new targets for trypanocidal drugs to emerge in recent years is
the cyclic AMP (cAMP) phosphodiesterase (PDE) activity encoded by TbrPDEB1 and …

The protozoan parasite Trypanosoma brucei engages in surface-induced social behavior,
termed social motility, characterized by single cells assembling into multicellular groups that …

Compared with the impressive progress in understanding signal transduction pathways and
mechanisms in mammalian systems, advances in protozoan signalling processes, including …