Role of the Power Function Value in Linearity and Universality for Charged Aerosol Detectors: Theoretical Elucidations from a Validated Model

TT Handlovic, D Roy, WW Barnhart… - Analytical …, 2024 - ACS Publications
High-throughput drug discovery on the microgram scale is now common, making analyte
quantitation without molecule-specific calibration imperative. The charged aerosol detector …

Development of HPLC-CAD method for simultaneous quantification of nine related substances in ursodeoxycholic acid and identification of two unknown impurities by …

Y Huang, H Lu, Z Li, Y Zeng, Q Xu, Y Wu - Journal of pharmaceutical and …, 2023 - Elsevier
Ursodeoxycholic acid has gained increasing attention due to its recent discovery of the
preventive effect on SARS-CoV-2 infection. Ursodeoxycholic acid has been included in …

Comprehensive reversed‐phase× chiral two‐dimensional liquid chromatography coupled to quadrupole‐time‐of‐flight tandem mass spectrometry with post‐first …

R Karongo, J Horak… - Journal of Separation …, 2023 - Wiley Online Library
This work describes a comprehensive achiral× chiral two‐dimensional liquid
chromatography separation for enantioselective amino acid analysis coupled to electrospray …

HPLC-CAD as a supplementary method for the quantification of related structure impurities for the purity assessment of organic CRMs

S Liu, B Lu, Z Peng, C Liu, Y Liu, H Jiao, D Wu… - Analytical and …, 2023 - Springer
In organic purity assessment, chromatography separation with a suitable detector is
required. Diode array detection (DAD) has been a widely used technique for high …

Digitally Enabled Generic Analytical Framework Accelerating the Pace of Liquid Chromatography Method Development for Vaccine Adjuvant Formulations

M Hemida, RC Barrientos, C Kinsey… - ACS Pharmacology & …, 2024 - ACS Publications
The growing use of adjuvants in the fast-paced formulation of new vaccines has created an
unprecedented need for meaningful analytical assays that deliver reliable quantitative data …

Impurity profiling of compound amino acid injection (6AA) using ion-pair high performance liquid chromatography coupled with corona-charged aerosol detection and …

X Qiu, L Zuo, S Sun, X Zhao, S Xu, Z Zhu, T Zhao… - … of Pharmaceutical and …, 2021 - Elsevier
The complex industrial production process of amino acids (AAs) leads to the existence of a
certain amount of impurities in Compound Amino Acid Injection (6AA). It is difficult to obtain …

[HTML][HTML] A simplified tutorial on charged aerosol detection: Understanding the basics, optimization, and troubleshooting

WW Barnhart, MQ Farooq, IAH Ahmad - Journal of Chromatography Open, 2024 - Elsevier
The charged aerosol detector (CAD) measures the overall charge deposited on aerosolized
particles to produce a signal proportional to the mass of analyte present, which applies to …

An optimization strategy for charged aerosol detection to linearize the detector response in the multicomponent quantitative analysis of Qishen Yiqi dripping pills

L Wu, X Gong, H Qu - Journal of Separation Science, 2024 - Wiley Online Library
Charged aerosol detection, increasingly recognized for quantifying pharmaceutical
compounds with weak ultraviolet absorption, is a universal detection technique for high …

[PDF][PDF] INTERNATIONAL JOURNAL OF EXPERIMENTAL AND BIOMEDICAL RESEARCH

P Harshitha, C Sakhinamma, YP Chandra - 2023 - academia.edu
HPLC-cad proposed a method through “Zhang” but also Victor it's us. The complete tool is
just corruption and bribery in use in conjugating verbs after all gas chromatograph but …

[PDF][PDF] Application of HPLC-CAD in Pharmaceutical Analysis

A Chaudhary - ijarst.in
High-performance liquid chromatography with charged aerosol detection (HPLC-CAD) has
emerged as a powerful technique for pharmaceutical analysis. This review aims to provide a …