Exosomes are well-known key mediators of intercellular communication and contribute to
various physiological and pathological processes. Their biogenesis involves four key steps …

Extracellular vesicles (EVs) are small vesicles released by donor cells that can be taken up
by recipient cells. Despite their discovery decades ago, it has only recently become …

Exosomes are generated within the multivesicular endosomes (MVEs) as intraluminal
vesicles (ILVs) and secreted during the fusion of MVEs with the cell membrane. The …

The participation of extracellular vesicles in many cellular processes, including reproduction,
is unquestionable. Although currently, the tetraspanin proteins found in extracellular vesicles …

Despite the extensive research on therapeutic delivery, many problems still exist on how to
develop a proper platform (a carrier) that can deliver drugs/nucleic acids to specific sites of …

There are many pathways of endocytosis at the cell surface that apparently operate at the
same time. With the advent of new molecular genetic and imaging tools, an understanding of …

Endocytosis is a fundamental process in which eukaryotic cells internalise molecules and
macromolecules via deformation of the membrane and generation of membrane-bound …

Curving biological membranes establishes the complex architecture of the cell and mediates
membrane traffic to control flux through subcellular compartments. Common molecular …

About twenty years ago, the functional lipid raft model of the plasma membrane was
published. It took into account decades of research showing that cellular membranes are not …

This brief overview of endocytic trafficking is written in honor of Renate Fuchs, who retires
this year. In the mid-1980s, Renate pioneered studies on the ion-conducting properties of …