Age-related hearing loss
MR Bowl, SJ Dawson - Cold Spring …, 2019 - perspectivesinmedicine.cshlp.org
Age-related hearing loss (ARHL) is the most prevalent sensory deficit in the elderly. This
progressive hearing impairment leads to social isolation and is also associated with …
progressive hearing impairment leads to social isolation and is also associated with …
The International Mouse Phenotyping Consortium: comprehensive knockout phenotyping underpinning the study of human disease
Abstract The International Mouse Phenotyping Consortium (IMPC; https://www.
mousephenotype. org/) web portal makes available curated, integrated and analysed …
mousephenotype. org/) web portal makes available curated, integrated and analysed …
Emerging approaches for restoration of hearing and vision
Impairments of vision and hearing are highly prevalent conditions limiting the quality of life
and presenting a major socioeconomic burden. For a long time, retinal and cochlear …
and presenting a major socioeconomic burden. For a long time, retinal and cochlear …
GWAS identifies 44 independent associated genomic loci for self-reported adult hearing difficulty in UK Biobank
Age-related hearing impairment (ARHI) is the most common sensory impairment in the
aging population; a third of individuals are affected by disabling hearing loss by the age of …
aging population; a third of individuals are affected by disabling hearing loss by the age of …
Mouse screen reveals multiple new genes underlying mouse and human hearing loss
NJ Ingham, SA Pearson, VE Vancollie, V Rook… - PLoS …, 2019 - journals.plos.org
Adult-onset hearing loss is very common, but we know little about the underlying molecular
pathogenesis impeding the development of therapies. We took a genetic approach to …
pathogenesis impeding the development of therapies. We took a genetic approach to …
A resource of targeted mutant mouse lines for 5,061 genes
MC Birling, A Yoshiki, DJ Adams, S Ayabe… - Nature …, 2021 - nature.com
A resource of targeted mutant mouse lines for 5,061 genes | Nature Genetics Skip to main
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Age-related hearing loss: sensory and neural etiology and their interdependence
KL Elliott, B Fritzsch, EN Yamoah… - Frontiers in aging …, 2022 - frontiersin.org
Age-related hearing loss (ARHL) is a common, increasing problem for older adults, affecting
about 1 billion people by 2050. We aim to correlate the different reductions of hearing from …
about 1 billion people by 2050. We aim to correlate the different reductions of hearing from …
Myosin motors in sensory hair bundle assembly
ZG Moreland, JE Bird - Current opinion in cell biology, 2022 - Elsevier
Mechanosensory hair bundles are assembled from actin-based stereocilia that project from
the apical surface of hair cells in the inner ear. Stereocilia architecture is critical for the …
the apical surface of hair cells in the inner ear. Stereocilia architecture is critical for the …
The International Mouse Phenotyping Consortium (IMPC): a functional catalogue of the mammalian genome that informs conservation
Abstract The International Mouse Phenotyping Consortium (IMPC) is building a catalogue of
mammalian gene function by producing and phenotyping a knockout mouse line for every …
mammalian gene function by producing and phenotyping a knockout mouse line for every …
Exome-wide evaluation of rare coding variants using electronic health records identifies new gene–phenotype associations
The clinical impact of rare loss-of-function variants has yet to be determined for most genes.
Integration of DNA sequencing data with electronic health records (EHRs) could enhance …
Integration of DNA sequencing data with electronic health records (EHRs) could enhance …