The aging of the immune system

D Weiskopf, B Weinberger… - Transplant …, 2009 - Wiley Online Library
An age‐related decline in immune functions, referred to as immunosenescence, is partially
responsible for the increased prevalence and severity of infectious diseases, and the low …

Kidney transplantation in the older adult

GA Knoll - American Journal of Kidney Diseases, 2013 - Elsevier
The end-stage renal disease population is aging. Nearly half of all new patients are older
than 65 years and one third are older than 70 years. Assessing the possibility of …

The combination of donor and recipient age is critical in determining host immunoresponsiveness and renal transplant outcome

SG Tullius, H Tran, I Guleria, SK Malek… - Annals of …, 2010 - journals.lww.com
Objective: To evaluate the interaction of donor and recipient age on transplant outcome and
immune response. Summary Background Data: The age of donor and recipient is becoming …

[HTML][HTML] Aspergillus colonization of the lung allograft is a risk factor for bronchiolitis obliterans syndrome

SS Weight, RM Elashoff, C Huang, A Ardehali… - American Journal of …, 2009 - Elsevier
Multiple infections have been linked with the development of bronchiolitis obliterans
syndrome (BOS) post-lung transplantation. Lung allograft airway colonization by Aspergillus …

Increased reactivity of dendritic cells from aged subjects to self-antigen, the human DNA

A Agrawal, J Tay, S Ton, S Agrawal… - The Journal of …, 2009 - journals.aai.org
Diminished immune functions and chronic inflammation are hallmarks of aging. The
underlying causes are not well understood. In this investigation, we show an increased …

[HTML][HTML] Risk factors for early graft failure and death after kidney transplantation in recipients older than 70 years

M Lemoine, DT Beauport, T Lobbedez… - Kidney international …, 2019 - Elsevier
Introduction Although kidney transplantation carries a survival benefit compared with
dialysis, mortality, especially the first year after transplantation, is high in recipients older …

Living donor kidney transplantation: the effects of donor age and gender on short-and long-term outcomes

CM Øien, AV Reisæter, T Leivestad, FW Dekker… - …, 2007 - journals.lww.com
Background. The influence of donor age and sex on acute rejection episodes and short-and
long-term graft survival in living donor (LD) kidney transplantation has not been well …

Patient and graft outcomes from deceased kidney donors age 70 years and older: an analysis of the Organ Procurement Transplant Network/United Network of Organ …

D Chavalitdhamrong, J Gill, S Takemoto… - …, 2008 - journals.lww.com
Background. The organ shortage has resulted in more use of older deceased donor kidneys.
Data are limited on the impact of donor aged 70 years and older on transplant outcomes. We …

Recipient age and risk for mortality after kidney transplantation in England

A Karim, D Farrugia, J Cheshire, S Mahboob… - …, 2014 - journals.lww.com
Background The aim of this study was to explore age-related mortality post-kidney
transplantation in England over the last decade. Methods This study used data from Hospital …

[HTML][HTML] Advantages of nonhuman primates as preclinical models for evaluating stem cell-based therapies for Parkinson's disease

DA Grow, JR McCarrey, CS Navara - Stem cell research, 2016 - Elsevier
The derivation of dopaminergic neurons from induced pluripotent stem cells brings new
hope for a patient-specific, stem cell-based replacement therapy to treat Parkinson's disease …