The development and application of optogenetics

L Fenno, O Yizhar, K Deisseroth - Annual review of …, 2011 - annualreviews.org
Genetically encoded, single-component optogenetic tools have made a significant impact on
neuroscience, enabling specific modulation of selected cells within complex neural tissues …

Optogenetic investigation of neural circuits in vivo

ME Carter, L de Lecea - Trends in molecular medicine, 2011 - cell.com
The recent development of light-activated optogenetic probes allows for the identification
and manipulation of specific neural populations and their connections in awake animals with …

Active expiration induced by excitation of ventral medulla in adult anesthetized rats

S Pagliardini, WA Janczewski, W Tan… - Journal of …, 2011 - Soc Neuroscience
Data from perinatal and juvenile rodents support our hypothesis that the preBötzinger
complex generates inspiratory rhythm and the retrotrapezoid nucleus–parafacial respiratory …

Role of parafacial nuclei in control of breathing in adult rats

RTR Huckstepp, KP Cardoza… - Journal of …, 2015 - Soc Neuroscience
Contiguous brain regions associated with a given behavior are increasingly being divided
into subregions associated with distinct aspects of that behavior. Using recently developed …

PreBötzinger complex neurons drive respiratory modulation of blood pressure and heart rate

C Menuet, AA Connelly, JK Bassi, MR Melo, S Le… - Elife, 2020 - elifesciences.org
Heart rate and blood pressure oscillate in phase with respiratory activity. A component of
these oscillations is generated centrally, with respiratory neurons entraining the activity of …

Locus coeruleus activation enhances thalamic feature selectivity via norepinephrine regulation of intrathalamic circuit dynamics

C Rodenkirch, Y Liu, BJ Schriver, Q Wang - Nature neuroscience, 2019 - nature.com
We investigated locus coeruleus (LC) modulation of thalamic feature selectivity through
reverse correlation analysis of single-unit recordings from different stages of the rat vibrissa …

The integrative role of orexin/hypocretin neurons in nociceptive perception and analgesic regulation

A Inutsuka, A Yamashita, S Chowdhury, J Nakai… - Scientific reports, 2016 - nature.com
The level of wakefulness is one of the major factors affecting nociception and pain. Stress-
induced analgesia supports an animal's survival via prompt defensive responses against …

A brainstem monosynaptic excitatory pathway that drives locomotor activities and sympathetic cardiovascular responses

S Koba, N Kumada, E Narai, N Kataoka… - Nature …, 2022 - nature.com
Exercise including locomotion requires appropriate autonomic cardiovascular adjustments
to meet the metabolic demands of contracting muscles, yet the functional brain architecture …

Control of breathing by raphe obscurus serotonergic neurons in mice

SD DePuy, R Kanbar, MB Coates… - Journal of …, 2011 - Soc Neuroscience
We used optogenetics to determine the global respiratory effects produced by selectively
stimulating raphe obscurus (RO) serotonergic neurons in anesthetized mice and to test …

Wireless Self‐Powered Optogenetic System for Long‐Term Cardiac Neuromodulation to Improve Post‐MI Cardiac Remodeling and Malignant Arrhythmia

L Zhou, Y Zhang, G Cao, C Zhang, C Zheng… - Advanced …, 2023 - Wiley Online Library
Autonomic imbalance is an important characteristic of patients after myocardial infarction
(MI) and adversely contributes to post‐MI cardiac remodeling and ventricular arrhythmias …