IL-2 was first identified as a growth factor capable of driving the expansion of activated
human T cell populations. In the more than 40 years since its discovery, a tremendous …

Immunotherapy that can activate immunity or enhance the immunogenicity of tumors has
emerged as one of the most effective methods for cancer therapy. Nevertheless, single …

Adoptive cell therapy (ACT) has proven to be highly effective in treating blood cancers, but
traditional approaches to ACT are poorly effective in treating solid tumors observed …

Abstract Cytokine therapy, involving interleukin-15 (IL-15), is a promising strategy for cancer
immunotherapy. However, clinical application has been limited due to severe toxicity and …

We describe a de novo computational approach for designing proteins that recapitulate the
binding sites of natural cytokines, but are otherwise unrelated in topology or amino acid …

Cytokines exert powerful immunomodulatory effects that are critical to physiology and
pathology in humans. The application of natural cytokines in clinical studies has not been …

The common cytokine receptor γ chain, γ c, is a component of the receptors for interleukin-2
(IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21. Mutation of the gene encoding γ c results in X-linked …

Cytokines are a class of potent immunoregulatory proteins that are secreted in response to
various stimuli and act locally to regulate many aspects of human physiology and disease …

Immune 'checkpoint'inhibitors can increase the activity of tumor-resident cytotoxic
lymphocytes and have revolutionized cancer treatment. Current therapies block inhibitory …

The functional role of CD8+ lymphocytes in tuberculosis remains poorly understood. We
depleted innate and/or adaptive CD8+ lymphocytes in macaques and showed that loss of all …