The discovery of leptin was intrinsically associated with its ability to regulate body weight.
However, the effects of leptin are more far-reaching and include profound glucose-lowering …

Childhood obesity is a leading public health problem worldwide, as it is increasingly
prevalent and therefore responsible for serious obesity-related comorbidities, not only in …

The physiological role of leptin is thought to be a driving force to reduce food intake and
increase energy expenditure. However, leptin therapies in the clinic have failed to effectively …

Metabolic health depends on the brain's ability to control food intake and nutrient use versus
storage, processes that require peripheral signals such as the adipocyte-derived hormone …

Abstract Background This Obesity Medicine Association (OMA) Clinical Practice Statement
(CPS) is intended to provide clinicians an overview of type 2 diabetes mellitus (T2DM), an …

It is well established that decreases in plasma leptin levels, as with fasting, signal starvation
and elicit appropriate physiological responses, such as increasing the drive to eat and …

Objective Hyperleptinemia per se is sufficient to promote leptin resistance in the obese state.
Leptin sensitivity can be restored by reducing circulating leptin levels within a …

Appetite control has been an important target for the treatment of obesity and associated
disorders. New studies have demonstrated promising adoption of dietary approaches …

Insulin action in the hypothalamus results in the suppression of hepatic glucose production
(HGP). Obesity is often associated with a diminished response to insulin, leading to impaired …

Objectives Insulin's ability to counterbalance catecholamine-induced lipolysis defines insulin
action in adipose tissue. Insulin suppresses lipolysis directly at the level of the adipocyte and …