Leveraging visual outcome measures to advance therapy development in neuroimmunologic disorders

JS Graves, FC Oertel, A Van der Walt… - Neurology …, 2021 - AAN Enterprises
The visual system offers unparalleled precision in the assessment of neuroaxonal damage.
With the majority of patients with multiple sclerosis (MS) experiencing afferent and efferent …

Paracentral acute middle maculopathy—review of the literature

N Moura-Coelho, T Gaspar, JT Ferreira… - Graefe's Archive for …, 2020 - Springer
Paracentral acute middle maculopathy (PAMM) is a recently identified spectral-domain
optical coherence tomography (SD-OCT) finding characterized by a hyper-reflective band …

Retinal optical coherence tomography in neuromyelitis optica

FC Oertel, S Specovius, HG Zimmermann… - Neurology …, 2021 - AAN Enterprises
Background and Objectives To determine optic nerve and retinal damage in aquaporin-4
antibody (AQP4-IgG)-seropositive neuromyelitis optica spectrum disorders (NMOSD) in a …

Diagnosis and classification of optic neuritis

A Petzold, CL Fraser, M Abegg, R Alroughani… - The Lancet …, 2022 - thelancet.com
There is no consensus regarding the classification of optic neuritis, and precise diagnostic
criteria are not available. This reality means that the diagnosis of disorders that have optic …

Imaging the optic nerve with optical coherence tomography

HJ Shin, F Costello - Eye, 2024 - nature.com
Optical coherence tomography (OCT) is a non-invasive imaging technology, which may be
used to generate in vivo quantitative and qualitative measures of retinal structure. In terms of …

Increased serum neurofilament light and thin ganglion cell–inner plexiform layer are additive risk factors for disease activity in early multiple sclerosis

TY Lin, V Vitkova, S Asseyer… - Neurology …, 2021 - AAN Enterprises
Objective To investigate the association of combined serum neurofilament light chain (sNfL)
and retinal optical coherence tomography (OCT) measurements with future disease activity …

Artificial intelligence extension of the OSCAR‐IB criteria

A Petzold, P Albrecht, L Balcer… - Annals of clinical …, 2021 - Wiley Online Library
Artificial intelligence (AI)‐based diagnostic algorithms have achieved ambitious aims
through automated image pattern recognition. For neurological disorders, this includes …

[HTML][HTML] Eye-brain connections revealed by multimodal retinal and brain imaging genetics in the UK Biobank

B Zhao, Y Li, Z Fan, Z Wu, J Shu, X Yang, Y Yang… - medRxiv, 2023 - ncbi.nlm.nih.gov
As an anatomical extension of the brain, the retina of the eye is synaptically connected to the
visual cortex, establishing physiological connections between the eye and the brain. Despite …

Retinal and choriocapillary vascular changes in early stages of multiple sclerosis: a prospective study

D Montorio, R Lanzillo, A Carotenuto… - Journal of Clinical …, 2021 - mdpi.com
Optical Coherence Tomography Angiography (OCTA) abnormalities occur in multiple
sclerosis (MS) over the course of the disease. OCTA investigations at early MS stages are …

Optical coherence tomography and visual evoked potentials as prognostic and monitoring tools in progressive multiple sclerosis

S Guerrieri, G Comi, L Leocani - Frontiers in Neuroscience, 2021 - frontiersin.org
Understanding the mechanisms underlying progression and developing new treatments for
progressive multiple sclerosis (PMS) are among the major challenges in the field of central …