Neuronal nicotinic acetylcholine receptors (nAChRs) are prototypical cation-selective, ligand-
gated ion channels that mediate fast neurotransmission in the central and peripheral …

The synapse is a localized neurohumoral contact between a neuron and an effector cell and
may be considered the quantum of fast intercellular communication. Analogously, the …

Nicotinic acetylcholine receptors are prototypes for the pharmaceutically important family of
pentameric ligand-gated ion channels. Here we present atomic resolution structures of …

The discovery of artemisinin more than 30 years ago provided a completely new antimalarial
structural prototype; that is, a molecule with a pharmacophoric peroxide bond in a unique 1 …

Upon ligand binding at the subunit interfaces, the extracellular domain of the nicotinic
acetylcholine receptor undergoes conformational changes, and agonist binding …

The crystal structure of the snake long α‐neurotoxin, α‐cobratoxin, bound to the pentameric
acetylcholine‐binding protein (AChBP) from Lymnaea stagnalis, was solved from good …

Ligand-gated ion channels (LGICs) mediate excitatory and inhibitory transmission in the
nervous system. Among them, the pentameric or 'Cys-loop'receptors (pLGICs) compose a …

Neurotransmitter receptors from the Cys-loop superfamily couple the binding of agonist to
the opening of an intrinsic ion pore in the final step in rapid synaptic transmission. Although …

Spirolide and gymnodimine macrocyclic imine phycotoxins belong to an emerging class of
chemical agents associated with marine algal blooms and shellfish toxicity. Analysis of 13 …

The pentameric acetylcholine‐binding protein (AChBP) is a soluble surrogate of the ligand
binding domain of nicotinic acetylcholine receptors. Agonists bind within a nest of aromatic …