Virulence Factors of Pseudomonas Aeruginosa and Antivirulence Strategies to Combat Its Drug Resistance

C Liao, X Huang, Q Wang, D Yao, W Lu - Frontiers in cellular and …, 2022 - frontiersin.org
Pseudomonas aeruginosa is an opportunistic pathogen causing nosocomial infections in
severely ill and immunocompromised patients. Ubiquitously disseminated in the …

Revisiting the virulence hallmarks of Pseudomonas aeruginosa: a chronicle through the perspective of quorum sensing

J Chadha, K Harjai, S Chhibber - Environmental microbiology, 2022 - Wiley Online Library
Pseudomonas aeruginosa is an opportunistic pathogen and the leading cause of mortality
among immunocompromised patients in clinical setups. The hallmarks of virulence in P …

Combining antibiotics with antivirulence compounds can have synergistic effects and reverse selection for antibiotic resistance in Pseudomonas aeruginosa

C Rezzoagli, M Archetti, I Mignot, M Baumgartner… - PLoS …, 2020 - journals.plos.org
Antibiotics are losing efficacy due to the rapid evolution and spread of resistance.
Treatments targeting bacterial virulence factors have been considered as alternatives …

Pyoverdine-Dependent Virulence of Pseudomonas aeruginosa Isolates From Cystic Fibrosis Patients

D Kang, AV Revtovich, Q Chen, KN Shah… - Frontiers in …, 2019 - frontiersin.org
The development of therapies that modulate or prevent pathogen virulence may be a key
strategy for circumventing antimicrobial resistance. Toward that end, we examined the …

Pseudomonas aeruginosa virulence attenuation by inhibiting siderophore functions

GJ Jeong, F Khan, S Khan, N Tabassum… - Applied Microbiology …, 2023 - Springer
Pseudmonas aeruginosa is a Gram-negative bacterium known to be ubiquitous and
recognized as one of the leading causes of infections such as respiratory, urinary tract …

Natural pigments of bacterial origin and their possible biomedical applications

RS Celedón, LB Díaz - Microorganisms, 2021 - mdpi.com
Microorganisms are considered one of the most promising niches for prospecting,
production, and application of bioactive compounds of biotechnological interest. Among …

Siderophores promote cooperative interspecies and intraspecies cross-protection against antibiotics in vitro

ACM Galdino, M Vaillancourt, D Celedonio… - Nature …, 2024 - nature.com
The antibiotic cefiderocol hijacks iron transporters to facilitate its uptake and resists β-
lactamase degradation. While effective, resistance has been detected clinically with …

Novel therapeutic strategies for treating Pseudomonas aeruginosa infection

X Shao, Y Xie, Y Zhang, J Liu, Y Ding… - Expert Opinion on …, 2020 - Taylor & Francis
Introduction: Persistent infections caused by the superbug Pseudomonas aeruginosa and its
resistance to multiple antimicrobial agents are huge threats to patients with cystic fibrosis as …

a dual-specificity Inhibitor targets polyphosphate kinase 1 and 2 enzymes to attenuate virulence of Pseudomonas aeruginosa

N Neville, N Roberge, X Ji, P Stephen, JL Lu, Z Jia - MBio, 2021 - Am Soc Microbiol
The opportunistic pathogen Pseudomonas aeruginosa is a leading cause of nosocomial
infections, which are becoming increasingly difficult to treat due to antibiotic resistance …

Iron acquisition and metabolism as a promising target for antimicrobials (bottlenecks and opportunities): where do we stand?

G Stelitano, M Cocorullo, M Mori, S Villa… - International Journal of …, 2023 - mdpi.com
The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) infections
is one of the most crucial challenges currently faced by the scientific community …