Acute chest syndrome (ACS) is a frequent cause of acute lung disease in children with sickle
cell disease (SCD). Patients may present with ACS or may develop this complication during …

Introduction Sickle cell disease, one of the world's most prevalent Mendelian disorders, is a
chronic hemolytic anemia punctuated by acute vasoocclusive events. Both hemolysis and …

1Department of Haematology, Guy's and St Thomas' NHS Foundation Trust, 2Lane Fox
Respiratory Unit, St Thomas' Hospital, Guy's and St Thomas' NHS Foundation Trust …

Background Globally, sickle cell disease (SCD) is one of the commonest severe monogenic
disorders, due to the inheritance of two abnormal haemoglobin (beta globin) genes. SCD …

Proper management of sickle cell anemia (SCA) begins with establishing the correct
diagnosis early in life, ideally during the newborn period. The identification of affected …

Introduction Acute chest syndrome (ACS) in sickle cell disease (SCD) is a serious condition
that carries with it a high rate of morbidity and mortality. Objective This review highlights the …

Acute chest syndrome (ACS) is a frequent cause of hospitalization in sickle cell disease
(SCD). Despite advances in acute care, many settings still lack knowledge about ACS best …

Background Sickle cell disease is an inherited autosomal recessive blood condition and is
one of the most prevalent genetic blood diseases worldwide. Acute chest syndrome is a …

Acute chest syndrome (ACS) is a major complication of sickle cell anaemia (SCA) and a
leading cause for hospital admissions and death. We aimed to study the spectrum of clinical …

BACKGROUND: There are scant data regarding the relative efficacy of exchange
transfusion (XC) versus simple transfusion (ST) for treatment of sickle cell anemia acute …