▪ Abstract Neurotransmitter release is mediated by exocytosis of synaptic vesicles at the
presynaptic active zone of nerve terminals. To support rapid and repeated rounds of release …

The physical distance between presynaptic Ca2+ channels and the Ca2+ sensors that
trigger exocytosis of neurotransmitter-containing vesicles is a key determinant of the …

Proteins critical for synaptic transmission are non-uniformly distributed and assembled into
regions of high density called subsynaptic densities (SSDs) that transsynaptically align in …

Action potential timing is fundamental to information processing; however, its determinants
are not fully understood. Here we report unexpected structural specializations in the Ranvier …

At presynaptic active zones, neurotransmitter release is initiated by the opening of voltage-
gated Ca 2+ channels close to docked vesicles. The mechanisms that enrich Ca 2+ …

Synaptic efficacy and precision are influenced by the coupling of voltage-gated Ca 2+
channels (VGCCs) to vesicles. But because the topography of VGCCs and their proximity to …

Perineuronal nets (PNNs) are specialized complexes of extracellular matrix molecules that
surround the somata of fast-spiking neurons throughout the vertebrate brain. PNNs are …

Glutamatergic synapses display variable strength and diverse short-term plasticity (STP),
even for a given type of connection. Using nonnegative tensor factorization and …

Summary Synaptotagmin-1 and-2 are known Ca 2+ sensors for fast synchronous
neurotransmitter release, but the potential Ca 2+-sensor functions of other synaptotagmins …

A fundamental organizing principle of auditory brain circuits is tonotopy, the orderly
representation of the sound frequency to which neurons are most sensitive. Tonotopy arises …