Natural and anthropogenic sources of metals in the ecosystem are perpetually increasing;
consequently, heavy metal (HM) accumulation has become a major environmental concern …

Copper (Cu) homeostasis is gaining increasing attention in human health as both Cu
overload and deficiency evokes pathological changes including cardiovascular diseases …

Cuproptosis, caused by excessively high copper concentrations, is urgently exploited as a
potential cancer therapeutic. However, the mechanisms underlying the initiation …

Background: Chemical and nonchemical environmental exposures are increasingly
suspected to influence the development of obesity, especially during early life, but studies …

Copper, an essential trace element that exists in oxidized and reduced forms, has pivotal
roles in a variety of biological processes, including redox chemistry, enzymatic reactions …

Metals are redox-active substances that participate in central biological processes and may
be involved in a multitude of pathogenic events. However, considering the inconsistencies …

Background Copper and lipid metabolism are intimately linked, sharing a complex, inverse
relationship in the periphery (outside of the central nervous system), which remains to be …

Copper (Cu) is an essential micronutrient for most organisms and serves mainly as a redox-
active catalytic centre in enzymes cycling between Cu+ and Cu 2+. Membrane transporters …

The essential trace mineral copper plays important roles in human physiology and
pathophysiology. Disruption of copper homeostasis may underlie the development of …

Background: Obesity and excess body weight are significant epidemiological issues, not
only because they are costly to treat, but also because they are among the leading causes of …