Periodontitis is a highly prevalent disease. As it progresses, it causes serious morbidity in
the form of periodontal abscesses and tooth loss and, in the latter stages, pain. It is also now …

Chondrocytes are responsible for the maintenance of the articular cartilage. A loss of
homeostasis in cartilage contributes to the development of osteoarthritis (OA) when the …

Abstract Nuclear Factor-Erythroid Factor 2 (Nrf2) is an important transcription factor that
regulates the expression of large number of genes in healthy and disease states. Nrf2 is …

Inflammatory Arthritis is characterized by synovial proliferation, neovascularization and
leukocyte extravasation leading to joint destruction and functional disability. Efficiency of …

Inflammatory bowel disease (IBD) is a chronic inflammatory state of the gastrointestinal tract
and can be classified into 2 main clinical phenomena: Crohn's disease (CD) and ulcerative …

Elevated levels of reactive oxygen species (ROS) have commonly been implicated in a
variety of diseases, including cancer, inflammation, and neurodegenerative diseases. In …

Oxidative stress (OS) represents a threat to the chemical integrity of biomolecules including
lipids, proteins, and DNA. The associated molecular damage frequently results in serious …

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovitis and
destruction of cartilage, promoted by sustained inflammation. However, current treatments …

A radical is any molecule that contains one or more unpaired electrons. Radicals are normal
products of many metabolic pathways. Some exist in a controlled (caged) form as they …

Metabolomic studies of body fluids show that immune‐mediated inflammatory diseases such
as rheumatoid arthritis (RA) are associated with metabolic disruption. This is likely to reflect …