Melanoma is the deadliest form of skin cancer and its incidence is rising, creating a costly
and significant clinical problem. Exposure to ultraviolet (UV) radiation, namely UVA (315 …

The growing incidence of melanoma is a serious public health issue that merits a thorough
understanding of potential causative risk factors, which includes exposure to ultraviolet …

The clinical use of molecular targeted therapy is rapidly evolving but has primarily focused
on genomic alterations. Transcriptomic analysis offers an opportunity to dissect the …

Although clonal neo-antigen burden is associated with improved response to immune
therapy, the functional basis for this remains unclear. Here we study this question in a novel …

Cancer genome instability arises from diverse defects in DNA-repair machinery, which make
cancer cells more susceptible to DNA targeting agents. The interrelation between DNA …

Ultraviolet (UV) light is absorbed by nucleic acids, proteins or other endogenous
chromophores, such as porphyrins, flavins and melanin, triggering biological processes in …

Failure in repairing ultraviolet radiation-induced DNA damage can lead to mutations and
cancer. Among UV-lesions, the pyrimidine–pyrimidone (6-4) photoproduct (6-4PP) is …

The incidence of cutaneous melanoma has been increasing worldwide, and melanoma
disproportionately contributes to skin cancer mortality. The pathogenesis of melanoma …

Metastasis is a formidable challenge in the prognosis of melanoma. Accurately predicting
the metastatic potential of non-metastatic melanoma (NMM) and determining effective …

Cutaneous melanoma accounts for at least> 10% of all cancers in adolescents and young
adults (AYA, 15–30 years of age) in Western countries. To date, little is known about the …