Innovations and advances in modelling and measuring pain in animals
Best practices in preclinical algesiometry (pain behaviour testing) have shifted over the past
decade as a result of technological advancements, the continued dearth of translational …
decade as a result of technological advancements, the continued dearth of translational …
The development and use of facial grimace scales for pain measurement in animals
The measurement of pain in animals is surprisingly complex, and remains a critical issue in
veterinary care and biomedical research. Based on the known utility of pain measurement …
veterinary care and biomedical research. Based on the known utility of pain measurement …
Anterior cingulate inputs to nucleus accumbens control the social transfer of pain and analgesia
ML Smith, N Asada, RC Malenka - Science, 2021 - science.org
INTRODUCTION Empathy, the adoption of another's sensory and emotional state, plays a
critical role in social interactions. Although, historically, empathy was often considered to be …
critical role in social interactions. Although, historically, empathy was often considered to be …
Neural circuits regulating prosocial behaviors
JJ Walsh, DJ Christoffel, RC Malenka - Neuropsychopharmacology, 2023 - nature.com
Positive, prosocial interactions are essential for survival, development, and well-being.
These intricate and complex behaviors are mediated by an amalgamation of neural circuit …
These intricate and complex behaviors are mediated by an amalgamation of neural circuit …
[HTML][HTML] Reproducibility and replicability of rodent phenotyping in preclinical studies
N Kafkafi, J Agassi, EJ Chesler, JC Crabbe… - Neuroscience & …, 2018 - Elsevier
The scientific community is increasingly concerned with the proportion of published
“discoveries” that are not replicated in subsequent studies. The field of rodent behavioral …
“discoveries” that are not replicated in subsequent studies. The field of rodent behavioral …
[HTML][HTML] Effect of simultaneous testing of two mice in the tail suspension test and forced swim test
H Ueno, Y Takahashi, S Murakami, K Wani… - Scientific reports, 2022 - nature.com
In mouse studies, the results of behavioural experiments are greatly affected by differences
in the experimental environment and handling methods. The Porsolt forced swim test and …
in the experimental environment and handling methods. The Porsolt forced swim test and …
MDMA enhances empathy-like behaviors in mice via 5-HT release in the nucleus accumbens
MDMA (3, 4-methylenedioxymethamphetamine) is a psychoactive drug with powerful
prosocial effects. While MDMA is sometimes termed an “empathogen,” empirical studies …
prosocial effects. While MDMA is sometimes termed an “empathogen,” empirical studies …
[HTML][HTML] Towards a unified theory of emotional contagion in rodents—A meta-analysis
J Hernandez-Lallement, P Gómez-Sotres… - … & Biobehavioral Reviews, 2022 - Elsevier
Here we leverage 80 years of emotional contagion research in rodents and perform the first
meta-analysis on this topic. Using 457 effect sizes, we show that, while both rats and mice …
meta-analysis on this topic. Using 457 effect sizes, we show that, while both rats and mice …
Alcohol and pain: a translational review of preclinical and clinical findings to inform future treatment strategies
Alcohol use disorder (AUD) and chronic pain are enduring and devastating conditions that
share an intersecting epidemiology and neurobiology. Chronic alcohol use itself can …
share an intersecting epidemiology and neurobiology. Chronic alcohol use itself can …
[HTML][HTML] Multimodal cues displayed by submissive rats promote prosocial choices by dominants
MJM Gachomba, J Esteve-Agraz, K Caref, AS Maroto… - Current Biology, 2022 - cell.com
Animals often display prosocial behaviors, performing actions that benefit others. Although
prosociality is essential for social bonding and cooperation, we still know little about how …
prosociality is essential for social bonding and cooperation, we still know little about how …