Innovations and advances in modelling and measuring pain in animals

KE Sadler, JS Mogil, CL Stucky - Nature Reviews Neuroscience, 2022 - nature.com
Best practices in preclinical algesiometry (pain behaviour testing) have shifted over the past
decade as a result of technological advancements, the continued dearth of translational …

The development and use of facial grimace scales for pain measurement in animals

JS Mogil, DSJ Pang, GGS Dutra… - … & Biobehavioral Reviews, 2020 - Elsevier
The measurement of pain in animals is surprisingly complex, and remains a critical issue in
veterinary care and biomedical research. Based on the known utility of pain measurement …

Anterior cingulate inputs to nucleus accumbens control the social transfer of pain and analgesia

ML Smith, N Asada, RC Malenka - Science, 2021 - science.org
INTRODUCTION Empathy, the adoption of another's sensory and emotional state, plays a
critical role in social interactions. Although, historically, empathy was often considered to be …

Neural circuits regulating prosocial behaviors

JJ Walsh, DJ Christoffel, RC Malenka - Neuropsychopharmacology, 2023 - nature.com
Positive, prosocial interactions are essential for survival, development, and well-being.
These intricate and complex behaviors are mediated by an amalgamation of neural circuit …

[HTML][HTML] Reproducibility and replicability of rodent phenotyping in preclinical studies

N Kafkafi, J Agassi, EJ Chesler, JC Crabbe… - Neuroscience & …, 2018 - Elsevier
The scientific community is increasingly concerned with the proportion of published
“discoveries” that are not replicated in subsequent studies. The field of rodent behavioral …

[HTML][HTML] Effect of simultaneous testing of two mice in the tail suspension test and forced swim test

H Ueno, Y Takahashi, S Murakami, K Wani… - Scientific reports, 2022 - nature.com
In mouse studies, the results of behavioural experiments are greatly affected by differences
in the experimental environment and handling methods. The Porsolt forced swim test and …

MDMA enhances empathy-like behaviors in mice via 5-HT release in the nucleus accumbens

B Rein, K Raymond, C Boustani, S Tuy, J Zhang… - Science …, 2024 - science.org
MDMA (3, 4-methylenedioxymethamphetamine) is a psychoactive drug with powerful
prosocial effects. While MDMA is sometimes termed an “empathogen,” empirical studies …

[HTML][HTML] Towards a unified theory of emotional contagion in rodents—A meta-analysis

J Hernandez-Lallement, P Gómez-Sotres… - … & Biobehavioral Reviews, 2022 - Elsevier
Here we leverage 80 years of emotional contagion research in rodents and perform the first
meta-analysis on this topic. Using 457 effect sizes, we show that, while both rats and mice …

Alcohol and pain: a translational review of preclinical and clinical findings to inform future treatment strategies

S Edwards, LF Vendruscolo, NW Gilpin… - Alcoholism: Clinical …, 2020 - Wiley Online Library
Alcohol use disorder (AUD) and chronic pain are enduring and devastating conditions that
share an intersecting epidemiology and neurobiology. Chronic alcohol use itself can …

[HTML][HTML] Multimodal cues displayed by submissive rats promote prosocial choices by dominants

MJM Gachomba, J Esteve-Agraz, K Caref, AS Maroto… - Current Biology, 2022 - cell.com
Animals often display prosocial behaviors, performing actions that benefit others. Although
prosociality is essential for social bonding and cooperation, we still know little about how …