Design of Coiled-coil Protein Nanostructures for Therapeutics and Drug Delivery
D Britton, JW Sun, PD Renfrew… - Annual Review of …, 2024 - annualreviews.org
Coiled-coil protein motifs have become widely employed in the design of biomaterials.
Some of these designs have been studied for use in drug delivery due to the unique ability …
Some of these designs have been studied for use in drug delivery due to the unique ability …
Coiled-Coil Protein Hydrogels Engineered with Minimized Fiber Diameters for Sustained Release of Doxorubicin in Triple-Negative Breast Cancer
Triple-negative breast cancer (TNBC) lacks expressed protein targets, making therapy
development challenging. Hydrogels offer a promising new route in this regard by improving …
development challenging. Hydrogels offer a promising new route in this regard by improving …
Computational Prediction of Coiled–Coil Protein Gelation Dynamics and Structure
Protein hydrogels represent an important and growing biomaterial for a multitude of
applications, including diagnostics and drug delivery. We have previously explored the …
applications, including diagnostics and drug delivery. We have previously explored the …
Genetically Fusing Order‐Promoting and Thermoresponsive Building Blocks to Design Hybrid Biomaterials
SS Patkar, B Wang, AM Mosquera… - Chemistry–A European …, 2024 - Wiley Online Library
The unique biophysical and biochemical properties of intrinsically disordered proteins
(IDPs) and their recombinant derivatives, intrinsically disordered protein polymers (IDPPs) …
(IDPs) and their recombinant derivatives, intrinsically disordered protein polymers (IDPPs) …
Genetic Fusion of Thermoresponsive Polypeptides with UCST‐type Behavior Mediates 1D Assembly of Coiled‐Coil Bundlemers
Thermoresponsive resilin‐like polypeptides (RLPs) of various lengths were genetically
fused to two different computationally designed coiled coil‐forming peptides with distinct …
fused to two different computationally designed coiled coil‐forming peptides with distinct …
Exosome Loaded Protein Hydrogel for Enhanced Gelation Kinetics and Wound Healing
Exosomes are being increasingly explored in biomedical research for wound healing
applications. Exosomes can improve blood circulation and endocrine signaling, resulting in …
applications. Exosomes can improve blood circulation and endocrine signaling, resulting in …
Protein-Engineered Fibers For Drug Encapsulation Traceable via 19F Magnetic Resonance
Theranostic materials research is experiencing rapid growth driven by the interest in
integrating both therapeutic and diagnostic modalities. These materials offer the unique …
integrating both therapeutic and diagnostic modalities. These materials offer the unique …
Dual coiled-coil protein domain mimic and drug delivery vehicle for SARS-CoV-2
SARS-CoV-2 has emerged as a strong target for the development of protein domain mimics
(PDMs) as it relies on the helical protein-protein interaction (PPI) between the N-terminal α …
(PDMs) as it relies on the helical protein-protein interaction (PPI) between the N-terminal α …
Fluorescent azobenzene-confined coiled-coil mesofibers
Fluorescent protein biomaterials have important applications such as bioimaging in
pharmacological studies. Self-assembly of proteins, especially into fibrils, is known to …
pharmacological studies. Self-assembly of proteins, especially into fibrils, is known to …
Collagen-targeted protein nanomicelles for the imaging of non-alcoholic steatohepatitis
In vivo molecular imaging tools hold immense potential to drive transformative
breakthroughs by enabling researchers to visualize cellular and molecular interactions in …
breakthroughs by enabling researchers to visualize cellular and molecular interactions in …