Design of Coiled-coil Protein Nanostructures for Therapeutics and Drug Delivery

D Britton, JW Sun, PD Renfrew… - Annual Review of …, 2024 - annualreviews.org
Coiled-coil protein motifs have become widely employed in the design of biomaterials.
Some of these designs have been studied for use in drug delivery due to the unique ability …

Coiled-Coil Protein Hydrogels Engineered with Minimized Fiber Diameters for Sustained Release of Doxorubicin in Triple-Negative Breast Cancer

D Britton, J Legocki, D Paul, O Katsara… - ACS Biomaterials …, 2024 - ACS Publications
Triple-negative breast cancer (TNBC) lacks expressed protein targets, making therapy
development challenging. Hydrogels offer a promising new route in this regard by improving …

Computational Prediction of Coiled–Coil Protein Gelation Dynamics and Structure

D Britton, LF Christians, C Liu, J Legocki… - …, 2023 - ACS Publications
Protein hydrogels represent an important and growing biomaterial for a multitude of
applications, including diagnostics and drug delivery. We have previously explored the …

Genetically Fusing Order‐Promoting and Thermoresponsive Building Blocks to Design Hybrid Biomaterials

SS Patkar, B Wang, AM Mosquera… - Chemistry–A European …, 2024 - Wiley Online Library
The unique biophysical and biochemical properties of intrinsically disordered proteins
(IDPs) and their recombinant derivatives, intrinsically disordered protein polymers (IDPPs) …

Genetic Fusion of Thermoresponsive Polypeptides with UCST‐type Behavior Mediates 1D Assembly of Coiled‐Coil Bundlemers

SS Patkar, Y Tang, AM Bisram, T Zhang… - Angewandte Chemie …, 2023 - Wiley Online Library
Thermoresponsive resilin‐like polypeptides (RLPs) of various lengths were genetically
fused to two different computationally designed coiled coil‐forming peptides with distinct …

Exosome Loaded Protein Hydrogel for Enhanced Gelation Kinetics and Wound Healing

D Britton, D Almanzar, Y Xiao, HW Shih… - ACS Applied Bio …, 2024 - ACS Publications
Exosomes are being increasingly explored in biomedical research for wound healing
applications. Exosomes can improve blood circulation and endocrine signaling, resulting in …

Protein-Engineered Fibers For Drug Encapsulation Traceable via 19F Magnetic Resonance

D Britton, J Legocki, O Aristizabal… - ACS Applied Nano …, 2023 - ACS Publications
Theranostic materials research is experiencing rapid growth driven by the interest in
integrating both therapeutic and diagnostic modalities. These materials offer the unique …

Dual coiled-coil protein domain mimic and drug delivery vehicle for SARS-CoV-2

D Britton, C Liu, S Jia, D Paul, J Legocki, Y Xiao… - Biochemical …, 2024 - Elsevier
SARS-CoV-2 has emerged as a strong target for the development of protein domain mimics
(PDMs) as it relies on the helical protein-protein interaction (PPI) between the N-terminal α …

Fluorescent azobenzene-confined coiled-coil mesofibers

K Punia, D Britton, K Hüll, L Yin, Y Wang, PD Renfrew… - Soft Matter, 2023 - pubs.rsc.org
Fluorescent protein biomaterials have important applications such as bioimaging in
pharmacological studies. Self-assembly of proteins, especially into fibrils, is known to …

Collagen-targeted protein nanomicelles for the imaging of non-alcoholic steatohepatitis

AL Wang, O Mishkit, H Mao, L Arivazhagan, T Dong… - Acta Biomaterialia, 2024 - Elsevier
In vivo molecular imaging tools hold immense potential to drive transformative
breakthroughs by enabling researchers to visualize cellular and molecular interactions in …