Vascular endothelial cell development and diversity

E Trimm, K Red-Horse - Nature Reviews Cardiology, 2023 - nature.com
Vascular endothelial cells form the inner layer of blood vessels where they have a key role
in the development and maintenance of the functional circulatory system and provide …

Endothelial to Mesenchymal Transition in Cardiovascular Disease: JACC State-of-the-Art Review

JC Kovacic, S Dimmeler, RP Harvey, T Finkel… - Journal of the American …, 2019 - jacc.org
Endothelial to mesenchymal transition (EndMT) is a process whereby an endothelial cell
undergoes a series of molecular events that lead to a change in phenotype toward a …

Capillary cell-type specialization in the alveolus

A Gillich, F Zhang, CG Farmer, KJ Travaglini, SY Tan… - Nature, 2020 - nature.com
In the mammalian lung, an apparently homogenous mesh of capillary vessels surrounds
each alveolus, forming the vast respiratory surface across which oxygen transfers to the …

Organotypic vasculature: from descriptive heterogeneity to functional pathophysiology

HG Augustin, GY Koh - Science, 2017 - science.org
BACKGROUND Each organ in the human body has its own capillary bed to carry out its
distinctive and versatile functions in response to dynamically changing systemic and local …

Revisiting cardiac cellular composition

AR Pinto, A Ilinykh, MJ Ivey, JT Kuwabara… - Circulation …, 2016 - Am Heart Assoc
Rationale: Accurate knowledge of the cellular composition of the heart is essential to fully
understand the changes that occur during pathogenesis and to devise strategies for tissue …

Vascular heterogeneity and specialization in development and disease

M Potente, T Mäkinen - Nature Reviews Molecular Cell Biology, 2017 - nature.com
Blood and lymphatic vessels pervade almost all body tissues and have numerous essential
roles in physiology and disease. The inner lining of these networks is formed by a single …

The deployment of cell lineages that form the mammalian heart

SM Meilhac, ME Buckingham - Nature Reviews Cardiology, 2018 - nature.com
The function of the mammalian heart depends on the interplay between different cardiac cell
types. The deployment of these cells, with precise spatiotemporal regulation, is also …

Lymphatic system in cardiovascular medicine

A Aspelund, MR Robciuc, S Karaman… - Circulation …, 2016 - Am Heart Assoc
The mammalian circulatory system comprises both the cardiovascular system and the
lymphatic system. In contrast to the blood vascular circulation, the lymphatic system forms a …

The cardiac lymphatic system stimulates resolution of inflammation following myocardial infarction

JM Vieira, S Norman, CV Del Campo… - The Journal of …, 2018 - Am Soc Clin Investig
Myocardial infarction (MI) arising from obstruction of the coronary circulation engenders
massive cardiomyocyte loss and replacement by non-contractile scar tissue, leading to …

Single-cell analysis of early progenitor cells that build coronary arteries

T Su, G Stanley, R Sinha, G d'Amato, S Das, S Rhee… - Nature, 2018 - nature.com
Arteries and veins are specified by antagonistic transcriptional programs. However, during
development and regeneration, new arteries can arise from pre-existing veins through a …