Modulating ROS to overcome multidrug resistance in cancer
The successful treatment of cancer has significantly improved as a result of targeted therapy
and immunotherapy. However, during chemotherapy, cancer cells evolve and can acquire …
and immunotherapy. However, during chemotherapy, cancer cells evolve and can acquire …
[HTML][HTML] Anti-carcinogenic glucosinolates in cruciferous vegetables and their antagonistic effects on prevention of cancers
P Soundararajan, JS Kim - Molecules, 2018 - mdpi.com
Glucosinolates (GSL) are naturally occurring β-d-thioglucosides found across the
cruciferous vegetables. Core structure formation and side-chain modifications lead to the …
cruciferous vegetables. Core structure formation and side-chain modifications lead to the …
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
D Trachootham, J Alexandre, P Huang - Nature reviews Drug discovery, 2009 - nature.com
Increased generation of reactive oxygen species (ROS) and an altered redox status have
long been observed in cancer cells, and recent studies suggest that this biochemical …
long been observed in cancer cells, and recent studies suggest that this biochemical …
[HTML][HTML] Inhibition of cancer antioxidant defense by natural compounds
A Sznarkowska, A Kostecka, K Meller, KP Bielawski - Oncotarget, 2017 - ncbi.nlm.nih.gov
All classic, non-surgical anticancer approaches like chemotherapy, radiotherapy or
photodynamic therapy kill cancer cells by inducing severe oxidative stress. Even tough …
photodynamic therapy kill cancer cells by inducing severe oxidative stress. Even tough …
Redox-directed cancer therapeutics: molecular mechanisms and opportunities
GT Wondrak - Antioxidants & redox signaling, 2009 - liebertpub.com
Redox dysregulation originating from metabolic alterations and dependence on mitogenic
and survival signaling through reactive oxygen species represents a specific vulnerability of …
and survival signaling through reactive oxygen species represents a specific vulnerability of …
[HTML][HTML] DNA damage by lipid peroxidation products: implications in cancer, inflammation and autoimmunity
F Gentile, A Arcaro, S Pizzimenti, M Daga… - AIMS …, 2017 - thieme-connect.com
Oxidative stress and lipid peroxidation (LPO) induced by inflammation, excess metal storage
and excess caloric intake cause generalized DNA damage, producing genotoxic and …
and excess caloric intake cause generalized DNA damage, producing genotoxic and …
Metabolic reprogramming orchestrates cancer stem cell properties in nasopharyngeal carcinoma
YA Shen, CY Wang, YT Hsieh, YJ Chen, YH Wei - Cell cycle, 2015 - Taylor & Francis
Cancer stem cells (CSCs) represent a subpopulation of tumor cells endowed with self-
renewal capacity and are considered as an underlying cause of tumor recurrence and …
renewal capacity and are considered as an underlying cause of tumor recurrence and …
[HTML][HTML] Ferroptosis: At the crossroad of gemcitabine resistance and tumorigenesis in pancreatic cancer
J Yang, J Xu, B Zhang, Z Tan, Q Meng, J Hua… - International Journal of …, 2021 - mdpi.com
The overall five-year survival rate of pancreatic cancer has hardly changed in the past few
decades (less than 10%) because of resistance to all known therapies, including …
decades (less than 10%) because of resistance to all known therapies, including …
Do reactive oxygen species play a role in myeloid leukemias?
PS Hole, RL Darley, A Tonks - Blood, The Journal of the …, 2011 - ashpublications.org
Reactive oxygen species (ROS) are a heterogeneous group of molecules that are generated
by mature myeloid cells during innate immune responses, and are also implicated in normal …
by mature myeloid cells during innate immune responses, and are also implicated in normal …
[HTML][HTML] Interfering with ROS metabolism in cancer cells: the potential role of quercetin
A main feature of cancer cells, when compared to normal ones, is a persistent pro-oxidative
state that leads to an intrinsic oxidative stress. Cancer cells have higher levels of reactive …
state that leads to an intrinsic oxidative stress. Cancer cells have higher levels of reactive …