The successful treatment of cancer has significantly improved as a result of targeted therapy
and immunotherapy. However, during chemotherapy, cancer cells evolve and can acquire …

Glucosinolates (GSL) are naturally occurring β-d-thioglucosides found across the
cruciferous vegetables. Core structure formation and side-chain modifications lead to the …

Increased generation of reactive oxygen species (ROS) and an altered redox status have
long been observed in cancer cells, and recent studies suggest that this biochemical …

All classic, non-surgical anticancer approaches like chemotherapy, radiotherapy or
photodynamic therapy kill cancer cells by inducing severe oxidative stress. Even tough …

Redox dysregulation originating from metabolic alterations and dependence on mitogenic
and survival signaling through reactive oxygen species represents a specific vulnerability of …

Oxidative stress and lipid peroxidation (LPO) induced by inflammation, excess metal storage
and excess caloric intake cause generalized DNA damage, producing genotoxic and …

Cancer stem cells (CSCs) represent a subpopulation of tumor cells endowed with self-
renewal capacity and are considered as an underlying cause of tumor recurrence and …

The overall five-year survival rate of pancreatic cancer has hardly changed in the past few
decades (less than 10%) because of resistance to all known therapies, including …

Reactive oxygen species (ROS) are a heterogeneous group of molecules that are generated
by mature myeloid cells during innate immune responses, and are also implicated in normal …

A main feature of cancer cells, when compared to normal ones, is a persistent pro-oxidative
state that leads to an intrinsic oxidative stress. Cancer cells have higher levels of reactive …