Cellular memory is provided by two counteracting groups of chromatin proteins termed
Trithorax group (TrxG) and Polycomb group (PcG) proteins. TrxG proteins activate …

Transcription is a highly dynamic process. Consequently, we have developed native
elongating transcript sequencing technology for mammalian chromatin (mNET-seq), which …

Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to
mark the transcription start sites of active genes. Here, we show that H3K4me3 domains that …

Transcriptional activation is a complex, multistage process implemented by hundreds of
proteins. Many transcriptional proteins are organized into coactivator complexes, which …

The Hippo pathway regulates growth through the transcriptional coactivator Yorkie, but how
Yorkie promotes transcription remains poorly understood. We address this by characterizing …

Histone H3 lysine 4 trimethylation (H3K4me3) is a major hallmark of promoter‐proximal
histones at transcribed genes. Here, we report that a previously uncharacterized Drosophila …

One of the most important questions in regenerative biology is to unveil how and when
genes change expression and trigger regeneration programs. The resetting of gene …

The interplay of active and repressive histone modifications is assumed to have a key role in
the regulation of gene expression. In contrast to this generally accepted view, we show that …

Large-scale sequencing techniques to chart genomes are entirely consolidated. Stable
computational methods to perform primary tasks such as quality control, read mapping, peak …

The importance of producing the correct numbers of neurons during development is
illustrated by both evolutionary enhancement of cognitive capacities in larger brains, and …