NAD+ metabolism and its roles in cellular processes during ageing
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme for redox reactions, making it
central to energy metabolism. NAD+ is also an essential cofactor for non-redox NAD+ …
central to energy metabolism. NAD+ is also an essential cofactor for non-redox NAD+ …
[HTML][HTML] Neuroprotection in glaucoma: mechanisms beyond intraocular pressure lowering
Glaucoma is a common, complex, multifactorial neurodegenerative disease characterized
by progressive dysfunction and then loss of retinal ganglion cells, the output neurons of the …
by progressive dysfunction and then loss of retinal ganglion cells, the output neurons of the …
[HTML][HTML] Small molecule SARM1 inhibitors recapitulate the SARM1−/− phenotype and allow recovery of a metastable pool of axons fated to degenerate
RO Hughes, T Bosanac, X Mao, TM Engber… - Cell reports, 2021 - cell.com
Axonal degeneration is responsible for disease progression and accumulation of disability
in many neurodegenerative conditions. The axonal degenerative process can generate a …
in many neurodegenerative conditions. The axonal degenerative process can generate a …
[HTML][HTML] SARM1 acts downstream of neuroinflammatory and necroptotic signaling to induce axon degeneration
Neuroinflammation and necroptosis are major contributors to neurodegenerative disease,
and axon dysfunction and degeneration is often an initiating event. SARM1 is the central …
and axon dysfunction and degeneration is often an initiating event. SARM1 is the central …
[HTML][HTML] Axonal energy metabolism, and the effects in aging and neurodegenerative diseases
Human studies consistently identify bioenergetic maladaptations in brains upon aging and
neurodegenerative disorders of aging (NDAs), such as Alzheimer's disease, Parkinson's …
neurodegenerative disorders of aging (NDAs), such as Alzheimer's disease, Parkinson's …
[HTML][HTML] SARM1 is a multi-functional NAD (P) ase with prominent base exchange activity, all regulated bymultiple physiologically relevant NAD metabolites
Summary SARM1 is an NAD (P) glycohydrolase and TLR adapter with an essential,
prodegenerative role in programmed axon death (Wallerian degeneration). Like other NAD …
prodegenerative role in programmed axon death (Wallerian degeneration). Like other NAD …
[HTML][HTML] SARM1 promotes neuroinflammation and inhibits neural regeneration after spinal cord injury through NF-κB signaling
H Liu, J Zhang, X Xu, S Lu, D Yang, C Xie, M Jia… - Theranostics, 2021 - ncbi.nlm.nih.gov
Axonal degeneration is a common pathological feature in many acute and chronic
neurological diseases such as spinal cord injury (SCI). SARM1 (sterile alpha and TIR motif …
neurological diseases such as spinal cord injury (SCI). SARM1 (sterile alpha and TIR motif …
[HTML][HTML] A SARM1-mitochondrial feedback loop drives neuropathogenesis in a Charcot-Marie-Tooth disease type 2A rat model
Y Sato-Yamada, A Strickland, Y Sasaki… - The Journal of …, 2022 - Am Soc Clin Investig
Charcot-Marie-Tooth disease type 2A (CMT2A) is an axonal neuropathy caused by
mutations in the mitofusin 2 (MFN2) gene. MFN2 mutations result in profound mitochondrial …
mutations in the mitofusin 2 (MFN2) gene. MFN2 mutations result in profound mitochondrial …
[HTML][HTML] Axons matter: the promise of treating neurodegenerative disorders by targeting SARM1-mediated axonal degeneration
R Krauss, T Bosanac, R Devraj, T Engber… - Trends in …, 2020 - cell.com
Attempts to develop neuroprotective treatments for neurodegenerative disorders have not
yet been clinically successful. Axonal degeneration has been recognized as a predominant …
yet been clinically successful. Axonal degeneration has been recognized as a predominant …
The SARM1 axon degeneration pathway: control of the NAD+ metabolome regulates axon survival in health and disease
MD Figley, A DiAntonio - Current opinion in neurobiology, 2020 - Elsevier
Highlights•A mechanistic understanding of the endogenous axon degeneration pathway has
emerged over the past few years.•Axonal health is maintained by a balance of survival …
emerged over the past few years.•Axonal health is maintained by a balance of survival …