Structural diversity and protein engineering of the aminoacyl-tRNA synthetases

JJ Perona, A Hadd - Biochemistry, 2012 - ACS Publications
Aminoacyl-tRNA synthetases (aaRS) are the enzymes that ensure faithful transmission of
genetic information in all living cells, and are central to the developing technologies for …

Site-specific incorporation of quadricyclane into a protein and photocleavage of the quadricyclane ligation adduct

FM Tomlin, CG Gordon, Y Han, TS Wu… - Bioorganic & medicinal …, 2018 - Elsevier
The quadricyclane (QC) ligation is a bioorthogonal reaction between a quadricyclane moiety
and a nickel bis (dithiolene) derivative. Here we show that a QC amino acid can be …

[图书][B] Chemical Approaches to the Study of N-Glycanase 1: Understanding NGLY1 Deficiency and Implications in Cancer Therapy

FM Tomlin - 2018 - search.proquest.com
Abstract N-Glycanase 1 (NGLY1) is the human cytosolic protein N-glycosidase. The
relationship between NGLY1 and the transcription factor Nrf1 is examined, particularly …

Improving unnatural amino acid mutagensis efficiency and selectivity in mammalian cell

E Al Saleem - 2016 - diva-portal.org
Genetically encoded, site-specific incorporation of unnatural amino acids (UAA) into proteins
through selective recoding of an amber stop codon provides a powerful route for expressing …