Influenza viruses cause annual epidemics and occasional pandemics of respiratory tract
infections that produce a wide spectrum of clinical disease severity in humans. The novel …

Fibrosis progression in the lung commonly results in impaired functional gas exchange,
respiratory failure, or even death. In addition to the aberrant activation and differentiation of …

Pulmonary fibrosis (PF) is a form of chronic lung disease characterized by pathologic
epithelial remodeling and accumulation of extracellular matrix (ECM). To comprehensively …

The respiratory system, which includes the trachea, airways, and distal alveoli, is a complex
multi-cellular organ that intimately links with the cardiovascular system to accomplish gas …

Alveolar epithelial type II cells (AT2) are a heterogeneous population that have critical
secretory and regenerative roles in the alveolus to maintain lung homeostasis. However …

The human lung plays vital roles in respiration, host defense, and basic physiology. Recent
technological advancements such as single-cell RNA sequencing and genetic lineage …

Simple Summary Lung cancer is the leading cause of cancer-related death worldwide, with
an average 5-year survival rate of approximately 15%. Among the multiple histological type …

Barrier tissues are populated by functionally plastic CD4+ resident memory T (TRM) cells.
Whether the barrier epithelium regulates CD4+ TRM cell locations, plasticity and activities …

Fibrosis is a pathologic process characterized by the replacement of parenchymal tissue by
large amounts of extracellular matrix, which may lead to organ dysfunction and even death …

Alveolar epithelium plays a pivotal role in protecting the lungs from inhaled infectious
agents. Therefore, the regenerative capacity of the alveolar epithelium is critical for recovery …