Given the rapid rate of population aging and the increased incidence of cognitive decline
and neurodegenerative diseases with advanced age, it is important to ascertain the …

Structural changes of neurons in the brain during aging are complex and not well
understood. Neurons have significant homeostatic control of essential brain functions …

Cognitive dysfunction in aging is a major biomedical challenge. Whether treatment with
klotho, a longevity factor, could enhance cognition in human-relevant models such as in …

A hallmark of electrophysiological brain activity is its 1/f-like spectrum–power decreases with
increasing frequency. The steepness of this 'roll-off'is approximated by the spectral …

The human brain is uniquely powerful with respect to cognitive abilities, yet the hippocampal
and neocortical circuits that mediate such complex functions are highly vulnerable to aging …

As it was established that aging is not associated with massive neuronal loss, as was
believed in the mid‐20th Century, scientific interest has addressed the influence of aging on …

Alterations in inhibitory interneurons contribute to cognitive deficits associated with several
psychiatric and neurological diseases. Phasic and tonic inhibition imparted by γ …

Brain networks that engage the hippocampus and prefrontal cortex are central for enabling
effective interactions with our environment. Some of the cognitive processes that these …

An electron microscopic analysis has been carried out on the effects of age on the numerical
density of both excitatory (asymmetric) and inhibitory (symmetric) synapses in the neuropil of …

Sleep slow waves (SWs) change considerably throughout normal aging. In humans, SWs
are generated and propagate on a structural backbone of highly interconnected cortical …