Conditional deletion of hippocampal CA2/CA3a oxytocin receptors impairs the persistence of long-term social recognition memory in mice

YT Lin, TY Hsieh, TC Tsai, CC Chen… - Journal of …, 2018 - Soc Neuroscience
Oxytocin (OXT) receptors (OXTRs) are prominently expressed in hippocampal CA2 and CA3
pyramidal neurons, but little is known about its physiological function. As the functional …

Environmental enrichment attenuates behavioral abnormalities in valproic acid-exposed autism model mice

H Yamaguchi, Y Hara, Y Ago, E Takano… - Behavioural brain …, 2017 - Elsevier
We recently demonstrated that prenatal exposure to valproic acid (VPA) at embryonic day
12.5 causes autism spectrum disorder (ASD)-like phenotypes such as hypolocomotion …

[HTML][HTML] CRISPR/Cas9-mediated CysLT1R deletion reverses synaptic failure, amyloidosis and cognitive impairment in APP/PS1 mice

F Chen, S Fang, Y Du, A Ghosh, MN Reed… - Aging (albany …, 2021 - ncbi.nlm.nih.gov
As a major pathological hallmark of Alzheimer's disease (AD), amyloid-β (Aβ) is regarded as
a causative factor for cognitive impairment. Extensive studies have found Aβ induces a …

Analysis of brain region-specific co-expression networks reveals clustering of established and novel genes associated with Alzheimer disease

D Lancour, J Dupuis, R Mayeux, JL Haines… - Alzheimer's research & …, 2020 - Springer
Background Identifying and understanding the functional role of genetic risk factors for
Alzheimer disease (AD) has been complicated by the variability of genetic influences across …

Conditional deletion of CC2D1A reduces hippocampal synaptic plasticity and impairs cognitive function through Rac1 hyperactivation

CY Yang, TH Yu, WL Wen, P Ling… - Journal of …, 2019 - Soc Neuroscience
Coiled-coil and C2 domain containing 1A (CC2D1A) is an evolutionarily conserved protein,
originally identified as a nuclear factor-κB activator through a large-scale screen of human …

Adolescent stress leads to glutamatergic disturbance through dopaminergic abnormalities in the prefrontal cortex of genetically vulnerable mice

Y Matsumoto, M Niwa, A Mouri, Y Noda… - …, 2017 - Springer
Background Stress during the adolescent period influences postnatal maturation and
behavioral patterns in adulthood. Adolescent stress-induced molecular and functional …

Infantile amnesia is related to developmental immaturity of the maintenance mechanisms for long-term potentiation

TC Tsai, CC Huang, KS Hsu - Molecular neurobiology, 2019 - Springer
Infantile amnesia (IA) refers to the inability of adults to recall episodic memories from infancy
or early childhood. While several hypotheses have been proposed to explain the occurrence …

Brain region-specific genome-wide deoxyribonucleic acid methylation analysis in patients with Alzheimer's disease

G Ren, S Song, SX Zhang, Y Liu, Y Lv… - Frontiers in Molecular …, 2023 - frontiersin.org
Objective Alzheimer's disease (AD) is a neurodegenerative disease characterized by
neuropathology and cognitive decline and associated with age. The comprehensive …

[HTML][HTML] Streptozotocin-induced diabetes mellitus affects the NMDA receptors: Role of caffeine administration in enhancing learning, memory and locomotor deficits

R Al Marshad, R Al Khatib, H Amer… - … Journal of Health …, 2018 - ncbi.nlm.nih.gov
Objective: To investigate the deterioration of the brain functions by diabetes mellitus (DM)
and the beneficial effect of caffeine. Materials and Methods: First, the component of N-methyl …

Hnrnpab regulates neural cell motility through transcription of Eps8

AA Lampasona, K Czaplinski - Rna, 2019 - rnajournal.cshlp.org
Cell migration requires a complicated network of structural and regulatory proteins. Changes
in cellular motility can impact migration as a result of cell-type or developmental stage …