Conditional deletion of hippocampal CA2/CA3a oxytocin receptors impairs the persistence of long-term social recognition memory in mice
YT Lin, TY Hsieh, TC Tsai, CC Chen… - Journal of …, 2018 - Soc Neuroscience
Oxytocin (OXT) receptors (OXTRs) are prominently expressed in hippocampal CA2 and CA3
pyramidal neurons, but little is known about its physiological function. As the functional …
pyramidal neurons, but little is known about its physiological function. As the functional …
Environmental enrichment attenuates behavioral abnormalities in valproic acid-exposed autism model mice
We recently demonstrated that prenatal exposure to valproic acid (VPA) at embryonic day
12.5 causes autism spectrum disorder (ASD)-like phenotypes such as hypolocomotion …
12.5 causes autism spectrum disorder (ASD)-like phenotypes such as hypolocomotion …
[HTML][HTML] CRISPR/Cas9-mediated CysLT1R deletion reverses synaptic failure, amyloidosis and cognitive impairment in APP/PS1 mice
As a major pathological hallmark of Alzheimer's disease (AD), amyloid-β (Aβ) is regarded as
a causative factor for cognitive impairment. Extensive studies have found Aβ induces a …
a causative factor for cognitive impairment. Extensive studies have found Aβ induces a …
Analysis of brain region-specific co-expression networks reveals clustering of established and novel genes associated with Alzheimer disease
Background Identifying and understanding the functional role of genetic risk factors for
Alzheimer disease (AD) has been complicated by the variability of genetic influences across …
Alzheimer disease (AD) has been complicated by the variability of genetic influences across …
Conditional deletion of CC2D1A reduces hippocampal synaptic plasticity and impairs cognitive function through Rac1 hyperactivation
CY Yang, TH Yu, WL Wen, P Ling… - Journal of …, 2019 - Soc Neuroscience
Coiled-coil and C2 domain containing 1A (CC2D1A) is an evolutionarily conserved protein,
originally identified as a nuclear factor-κB activator through a large-scale screen of human …
originally identified as a nuclear factor-κB activator through a large-scale screen of human …
Adolescent stress leads to glutamatergic disturbance through dopaminergic abnormalities in the prefrontal cortex of genetically vulnerable mice
Y Matsumoto, M Niwa, A Mouri, Y Noda… - …, 2017 - Springer
Background Stress during the adolescent period influences postnatal maturation and
behavioral patterns in adulthood. Adolescent stress-induced molecular and functional …
behavioral patterns in adulthood. Adolescent stress-induced molecular and functional …
Infantile amnesia is related to developmental immaturity of the maintenance mechanisms for long-term potentiation
TC Tsai, CC Huang, KS Hsu - Molecular neurobiology, 2019 - Springer
Infantile amnesia (IA) refers to the inability of adults to recall episodic memories from infancy
or early childhood. While several hypotheses have been proposed to explain the occurrence …
or early childhood. While several hypotheses have been proposed to explain the occurrence …
Brain region-specific genome-wide deoxyribonucleic acid methylation analysis in patients with Alzheimer's disease
G Ren, S Song, SX Zhang, Y Liu, Y Lv… - Frontiers in Molecular …, 2023 - frontiersin.org
Objective Alzheimer's disease (AD) is a neurodegenerative disease characterized by
neuropathology and cognitive decline and associated with age. The comprehensive …
neuropathology and cognitive decline and associated with age. The comprehensive …
[HTML][HTML] Streptozotocin-induced diabetes mellitus affects the NMDA receptors: Role of caffeine administration in enhancing learning, memory and locomotor deficits
R Al Marshad, R Al Khatib, H Amer… - … Journal of Health …, 2018 - ncbi.nlm.nih.gov
Objective: To investigate the deterioration of the brain functions by diabetes mellitus (DM)
and the beneficial effect of caffeine. Materials and Methods: First, the component of N-methyl …
and the beneficial effect of caffeine. Materials and Methods: First, the component of N-methyl …
Hnrnpab regulates neural cell motility through transcription of Eps8
AA Lampasona, K Czaplinski - Rna, 2019 - rnajournal.cshlp.org
Cell migration requires a complicated network of structural and regulatory proteins. Changes
in cellular motility can impact migration as a result of cell-type or developmental stage …
in cellular motility can impact migration as a result of cell-type or developmental stage …