Structural diversity, characterization and toxicology of microcystins

N Bouaïcha, CO Miles, DG Beach, Z Labidi, A Djabri… - Toxins, 2019 - mdpi.com
Hepatotoxic microcystins (MCs) are the most widespread class of cyanotoxins and the one
that has most often been implicated in cyanobacterial toxicosis. One of the main challenges …

Natural product biosynthetic diversity and comparative genomics of the cyanobacteria

E Dittmann, M Gugger, K Sivonen, DP Fewer - Trends in microbiology, 2015 - cell.com
Cyanobacteria are an ancient lineage of slow-growing photosynthetic bacteria and a prolific
source of natural products with intricate chemical structures and potent biological activities …

Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing

PM Shih, D Wu, A Latifi, SD Axen… - Proceedings of the …, 2013 - National Acad Sciences
The cyanobacterial phylum encompasses oxygenic photosynthetic prokaryotes of a great
breadth of morphologies and ecologies; they play key roles in global carbon and nitrogen …

Cyanobacterial toxins: biosynthetic routes and evolutionary roots

E Dittmann, DP Fewer, BA Neilan - FEMS microbiology reviews, 2013 - academic.oup.com
Cyanobacteria produce an unparalleled variety of toxins that can cause severe health
problems or even death in humans, and wild or domestic animals. In the last decade …

The cyanotoxin-microcystins: current overview

RP Rastogi, RP Sinha, A Incharoensakdi - Reviews in Environmental …, 2014 - Springer
The monocyclic heptapeptides microcystins (MCs), are a group of hepatotoxins, produced
worldwide by some bloom-forming cyanobacterial species/strains both in marine and …

Appendix 3: Tables of microcystins and nodularins

L Spoof, A Catherine - Handbook of cyanobacterial monitoring …, 2016 - Wiley Online Library
The number of known microcystin (MC) congeners has increased rapidly in recent years as
more sensitive mass spectrometric techniques have enabled the detection of MCs and …

[HTML][HTML] Toxic benthic freshwater cyanobacterial proliferations: Challenges and solutions for enhancing knowledge and improving monitoring and mitigation

SA Wood, L Kelly, K Bouma-Gregson… - Freshwater …, 2020 - ncbi.nlm.nih.gov
Toxic benthic freshwater cyanobacterial proliferations: Challenges and solutions for
enhancing knowledge and improving monitoring and mitigation - PMC Back to Top Skip to …

High Levels of Structural Diversity Observed in Microcystins from Microcystis CAWBG11 and Characterization of Six New Microcystin Congeners

J Puddick, MR Prinsep, SA Wood, SAF Kaufononga… - Marine drugs, 2014 - mdpi.com
Microcystins (MCs) are cyclic peptides produced by cyanobacteria, which can be harmful to
humans and animals when ingested. Differences in the coding of the non-ribosomal peptide …

[HTML][HTML] Role of toxic and bioactive secondary metabolites in colonization and bloom formation by filamentous cyanobacteria Planktothrix

R Kurmayer, L Deng, E Entfellner - Harmful algae, 2016 - Elsevier
Bloom-forming cyanobacteria Planktothrix agardhii and P. rubescens are regularly involved
in the occurrence of cyanotoxin in lakes and reservoirs. Besides microcystins (MCs), which …

Efficient rational modification of non-ribosomal peptides by adenylation domain substitution

MJ Calcott, JG Owen, DF Ackerley - Nature communications, 2020 - nature.com
Non-ribosomal peptide synthetase (NRPS) enzymes form modular assembly-lines, wherein
each module governs the incorporation of a specific monomer into a short peptide product …