R-loops are three-stranded structures that harbour an RNA–DNA hybrid and frequently form
during transcription. R-loop misregulation is associated with DNA damage, transcription …

During transcription, the nascent RNA strand can base pair with its template DNA, displacing
the non-template strand as ssDNA and forming a structure called an R-loop. R-loops are …

Cleavage under targets and release using nuclease (CUT&RUN) is an epigenomic profiling
strategy in which antibody-targeted controlled cleavage by micrococcal nuclease releases …

DNA-RNA hybrids play a physiological role in cellular processes, but often, they represent
non-scheduled co-transcriptional structures with a negative impact on transcription …

R-loop, a three-stranded RNA/DNA structure, has been linked to induced genome instability
and regulated gene expression. To enable precision analysis of R-loops in vivo, we develop …

Single-stranded genomic DNA can fold into G-quadruplex (G4) structures or form DNA: RNA
hybrids (R loops). Recent evidence suggests that such non-canonical DNA structures affect …

R-loops are prevalent three-stranded non-B DNA structures composed of an RNA–DNA
hybrid and a single strand of DNA. R-loops are implicated in various basic nuclear …

Replication-transcription collisions shape genomes, influence evolution, and promote
genetic diseases. Although unclear why, head-on transcription (lagging strand genes) is …

Genomic DNA and cellular RNAs can form a variety of non-B secondary structures, including
G-quadruplex (G4) and R-loops. G4s are constituted by stacked guanine tetrads held …

Transcription and replication both require large macromolecular complexes to act on a DNA
template, yet these machineries cannot simultaneously act on the same DNA sequence …