The mechanism of genome replication and transcription in bunyaviruses

H Malet, HM Williams, S Cusack, M Rosenthal - PLoS pathogens, 2023 - journals.plos.org
Bunyaviruses are negative sense, single-strand RNA viruses that infect a wide range of
vertebrate, invertebrate and plant hosts. WHO lists three bunyavirus diseases as priority …

The cap-snatching mechanism of bunyaviruses

S Olschewski, S Cusack, M Rosenthal - Trends in microbiology, 2020 - cell.com
In common with all segmented negative-sense RNA viruses, bunyavirus transcripts contain
heterologous sequences at their 5′ termini originating from capped host cell RNAs. These …

Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein

HM Williams, SR Thorkelsson, D Vogel… - Nucleic acids …, 2023 - academic.oup.com
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a phenuivirus that has
rapidly become endemic in several East Asian countries. The large (L) protein of SFTSV …

Structural and functional characterization of the severe fever with thrombocytopenia syndrome virus L protein

D Vogel, SR Thorkelsson, ERJ Quemin… - Nucleic acids …, 2020 - academic.oup.com
The Bunyavirales order contains several emerging viruses with high epidemic potential,
including Severe fever with thrombocytopenia syndrome virus (SFTSV). The lack of medical …

Structural snapshots of phenuivirus cap-snatching and transcription

HM Williams, SR Thorkelsson, D Vogel… - Nucleic Acids …, 2024 - academic.oup.com
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a human pathogen that is
now endemic to several East Asian countries. The viral large (L) protein catalyzes viral …

[HTML][HTML] Diketo acids inhibit the cap-snatching endonuclease of several Bunyavirales

Y Fernández-García, S Ter Horst, M Bassetto… - Antiviral Research, 2020 - Elsevier
Several fatal bunyavirus infections lack specific treatment. Here, we show that diketo acids
engage a panel of bunyavirus cap-snatching endonucleases, inhibit their catalytic activity …

Structure of severe fever with thrombocytopenia syndrome virus L protein elucidates the mechanisms of viral transcription initiation

P Wang, L Liu, A Liu, L Yan, Y He, S Shen, M Hu… - Nature …, 2020 - nature.com
Segmented negative-sense RNA viruses (sNSRVs) encode a single-polypeptide
polymerase (L protein) or a heterotrimeric polymerase complex to cannibalize host …

The cap-snatching SFTSV endonuclease domain is an antiviral target

W Wang, WJ Shin, B Zhang, Y Choi, JS Yoo… - Cell reports, 2020 - cell.com
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne virus with 12%–
30% case mortality rates and is related to the Heartland virus (HRTV) identified in the United …

Antiviral Activity of Acetylsalicylic Acid against Bunyamwera Virus in Cell Culture

SY Fernández-Sánchez, JP Cerón-Carrasco, C Risco… - Viruses, 2023 - mdpi.com
The Bunyavirales order is a large group of RNA viruses that includes important pathogens
for humans, animals and plants. With high-throughput screening of clinically tested …

Genetic variants of Dabie bandavirus: classification and biological/clinical implications

B Liu, J Zhu, T He, Z Zhang - Virology Journal, 2023 - Springer
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease
caused by Dabie bandavirus (DBV), a novel Bandavirus in the family Phenuiviridae. The first …