The high osmolarity glycerol (HOG) pathway in fungi

H Yaakoub, NS Sanchez, L Ongay-Larios… - Critical Reviews in …, 2022 - Taylor & Francis
While fungi are widely occupying nature, many species are responsible for devastating
mycosis in humans. Such niche diversity explains how quick fungal adaptation is necessary …

Crucial aspects of metabolism and cell biology relating to industrial production and processing of Saccharomyces biomass

PV Attfield - Critical Reviews in Biotechnology, 2023 - Taylor & Francis
The multitude of applications to which Saccharomyces spp. are put makes these yeasts the
most prolific of industrial microorganisms. This review considers biological aspects …

Heat-stress triggers MAPK crosstalk to turn on the hyperosmotic response pathway

P Dunayevich, R Baltanás, JA Clemente, A Couto… - Scientific Reports, 2018 - nature.com
Cells make decisions based on a combination of external and internal signals. In yeast, the
high osmolarity response (HOG) is a mitogen-activated protein kinase (MAPK) pathway that …

Extreme osmotolerance and halotolerance in food-relevant yeasts and the role of glycerol-dependent cell individuality

M Stratford, H Steels, M Novodvorska… - Frontiers in …, 2019 - frontiersin.org
Osmotolerance or halotolerance are used to describe resistance to sugars and salt, or only
salt, respectively. Here, a comprehensive screen of more than 600 different yeast isolates …

The Aspergillus fumigatus phosphoproteome reveals roles of high-osmolarity glycerol mitogen-activated protein kinases in promoting cell wall damage and …

EC Mattos, LP Silva, C Valero, PA de Castro… - MBio, 2020 - Am Soc Microbiol
The filamentous fungus Aspergillus fumigatus can cause a distinct set of clinical disorders in
humans. Invasive aspergillosis (IA) is the most common life-threatening fungal disease of …

Eukaryotic cell biology is temporally coordinated to support the energetic demands of protein homeostasis

JS O'Neill, NP Hoyle, JB Robertson, RS Edgar… - Nature …, 2020 - nature.com
Yeast physiology is temporally regulated, this becomes apparent under nutrient-limited
conditions and results in respiratory oscillations (YROs). YROs share features with circadian …

Yeast two‐and three‐species hybrids and high‐sugar fermentation

M Sipiczki - Microbial biotechnology, 2019 - Wiley Online Library
The dominating strains of most sugar‐based natural and industrial fermentations either
belong to Saccharomyces cerevisiae and Saccharomyces uvarum or are their chimeric …

Exploring the role of stromal osmoregulation in cancer and disease using executable modelling

D Shorthouse, A Riedel, E Kerr, L Pedro… - Nature …, 2018 - nature.com
Osmotic regulation is a vital homoeostatic process in all cells and tissues. Cells initially
respond to osmotic stresses by activating transmembrane transport proteins to move …

The Effect of Lithium on the Budding Yeast Saccharomyces cerevisiae upon Stress Adaptation

P Reith, S Braam, N Welkenhuysen, S Lecinski… - Microorganisms, 2022 - mdpi.com
Lithium salts are used in the treatment of mood disorders, cancer, and Alzheimer's disease.
It has been shown to prolong life span in several phyla; however, not yet in budding yeast. In …

Osmolyte homeostasis controls single-cell growth rate and maximum cell size of Saccharomyces cerevisiae

T Altenburg, B Goldenbogen, J Uhlendorf… - NPJ systems biology …, 2019 - nature.com
Cell growth is well described at the population level, but precisely how nutrient and water
uptake and cell wall expansion drive the growth of single cells is poorly understood …