Nucleotide second messengers act as intracellular 'secondary'signals that represent
environmental or cellular cues, ie the 'primary'signals. As such, they are linking sensory …

Nucleotides are at the heart of the most essential biological processes in the cell, be it as
key protagonists in the dogma of molecular biology or by regulating multiple metabolic …

Abstract Terminal deoxynucleotidyl Transferase (TdT) is a template‐independent DNA
polymerase that plays an essential role in the human adaptive immune system and is …

Purine nucleotides, generated by de novo synthesis and salvage pathways, are essential for
metabolism and act as building blocks of genetic material. To avoid an imbalance in the …

Allosteric regulation of inosine 5′-monophosphate dehydrogenase (IMPDH), an essential
enzyme of purine metabolism, contributes to the homeostasis of adenine and guanine …

The opportunistic bacterial pathogen Pseudomonas aeruginosa causes a wide range of
infections that are difficult to treat, largely because of the spread of antibiotic-resistant …

Regulatory adenine nucleotide-binding cystathionine β-synthase (CBS) domains are
widespread in proteins; however, information on the mechanism of their modulating effects …

Cyclic di-guanosine monophosphate (c-di-GMP) is a bacterial second messenger that
governs the lifestyle switch between planktonic and biofilm states. While substantial …

Highlights•Bacteria utilize nucleotide second messengers such as (p) ppGpp as stress
regulators.•Crosstalk exists between nucleotide second messenger signaling pathways.•(p) …

ABSTRACT RNA capping is a prominent RNA modification that influences RNA stability,
metabolism, and function. While it was long limited to the study of the most abundant …