Secretion of growth hormone (GH), and consequently that of insulin-like growth factor 1 (IGF-
1), declines over time until only low levels can be detected in individuals aged≥ 60 years …

Genetic and pharmacological intervention studies have identified evolutionarily conserved
and functionally interconnected networks of cellular energy homeostasis, nutrient-sensing …

Dopamine is a small and relatively simple molecule that fulfills diverse functions. Within the
brain, it acts as a classical neurotransmitter whose attenuation or overactivity can result in …

The hypothalamus‐pituitary‐thyroid (HPT) axis determines the set point of thyroid hormone
(TH) production. Hypothalamic thyrotropin‐releasing hormone (TRH) stimulates the …

The oxidative stress theory of aging predicts that manipulations that alter oxidative
stress/damage will alter aging. The gold standard for determining whether aging is altered is …

Growth hormone (GH) is a key determinant of postnatal growth and plays an important role
in the control of metabolism and body composition. Surprisingly, deficiency in GH signaling …

Single-gene mutations that extend lifespan provide valuable tools for the exploration of the
molecular basis for age-related changes in cell and tissue function and for the …

Precise control of transcriptional programmes underlying metazoan development is
modulated by enzymatically active co-regulatory complexes, coupled with epigenetic …

Normal hypothalamopituitary development is closely related to that of the forebrain and is
dependent upon a complex genetic cascade of transcription factors and signaling molecules …

The gene regulatory apparatus that directs development is encoded in the DNA, in the form
of organized arrays of transcription factor target sites. Genes are regulated by interactions …