Since prion infectivity had never been reported in milk, dairy products originating from
transmissible spongiform encephalopathy (TSE)-affected ruminant flocks currently enter …

Background Diagnosis based on prion detection in lymph nodes of sheep and goats can
improve active surveillance for scrapie and, if it were circulating, for bovine spongiform …

Scrapie, a naturally occurring prion disease affecting goats and sheep, comprises classical
and atypical forms, with classical scrapie being the archetype of transmissible spongiform …

Samples of tissue from the central nervous system (cns), the lymphoreticular system (lrs) and
the rectal mucosa of a large number of scrapie‐exposed sheep, with and without signs of …

Specific variations in the amino acid sequence of prion protein (PrP) are key determinants of
susceptibility to prion diseases. We previously showed that an amino acid substitution …

In classical scrapie, detection of PrPsc on lymphoreticular system is used for the in vivo and
post mortem diagnosis of the disease. However, the sensitivity of this methodology is not …

Objective—To determine the suitability and estimate the sensitivity of an
immunohistochemical (IHC) test for disease-associated prion protein (PrP Sc) in biopsy …

Caprine arthritis encephalitis virus (CAEV) is a lentivirus that infects both goats and sheep
and is closely related to maedi-visna virus that infects sheep; collectively, these viruses are …

Neurodegenerative diseases are characterised by neuronal loss and abnormal deposition
of pathological proteins in the nervous system. Among the most common neurodegenerative …

Selection based on scrapie genotypes could improve the genetic resistance for scrapie in
sheep. However, in practice, few animals are genotyped. The objectives were to define …