The endosomal system is expansive and complex, characterized by swift morphological
transitions, dynamic remodeling of membrane constituents, and intracellular positioning …

Clathrin-mediated endocytosis is an essential cellular mechanism by which all eukaryotic
cells regulate their plasma membrane composition to control processes ranging from cell …

Nanomedicines (NMs) have played an increasing role in cancer therapy as carriers to
efficiently deliver therapeutics into tumor cells. For this application, the uptake of NMs by …

Clathrin is considered the prototype vesicle coat protein whose self-assembly mediates
sorting of membrane cargo and recruitment of lipid modifiers. Detailed knowledge of clathrin …

Clathrin-mediated endocytosis (CME) is the main mechanism by which mammalian cells
control their cell surface proteome. Proper operation of the pivotal CME cargo adaptor AP2 …

Clathrin-coated vesicles form by rapid assembly of discrete coat constituents into a cargo-
sorting lattice. How the sequential phases of coat construction are choreographed is …

The AP2 clathrin adaptor complex links protein cargo to the endocytic machinery but it is
unclear how AP2 is activated on the plasma membrane. Here we demonstrate that the …

Heterotetrameric clathrin adaptor protein complexes (APs) orchestrate the formation of
coated vesicles for transport among organelles of the cell periphery. AP1 binds membranes …

Clathrin-mediated endocytosis (CME) is a central trafficking pathway in eukaryotic cells
regulated by phosphoinositides. The plasma membrane phosphatidylinositol-4, 5 …

APOE allelic variation is critical in brain aging and Alzheimer's disease (AD). The APOE2
allele associated with cognitive resilience and neuroprotection against AD remains …