Most mitochondrial proteins are synthesized on cytosolic ribosomes and must be imported
across one or both mitochondrial membranes. There is an amazingly versatile set of …

The majority of proteins localised to mitochondria are encoded by the nuclear genome, with
approximately 1500 proteins imported into mammalian mitochondria. Dysfunction in this …

Apoptosis-inducing factor (AIF) is a mitochondrial flavoprotein that, beyond its apoptotic
function, is required for the normal expression of major respiratory chain complexes. Here …

MIA40 has a key role in oxidative protein folding in the mitochondrial intermembrane space.
We present the solution structure of human MIA40 and its mechanism as a catalyst of …

Mitochondria critically rely on protein import and its tight regulation. Here, we found that the
complex I assembly factor NDUFAF8 follows a two-step import pathway linking IMS and …

Mitochondria are double-membrane organelles that contain their own genome, the
mitochondrial DNA (mtDNA), and reminiscent of its endosymbiotic origin. Mitochondria are …

All proteins of the intermembrane space of mitochondria are encoded by nuclear genes and
synthesized in the cytosol. Many of these proteins lack presequences but are imported into …

Members of the coiled-coil-helix-coiled-coil-helix (CHCH) domain-containing protein family
that carry (CX 9 C) type motifs are imported into the mitochondrion with the help of the …

Mitochondria are fundamental structures that fulfil important and diverse functions within
cells, including cellular respiration and iron-sulfur cluster biogenesis. Mitochondrial function …

Mitochondrial precursor proteins are synthesized in the cytosol and subsequently imported
into mitochondria. The import of mitochondrial intermembrane space proteins is coupled …