The role of 5-HT1A receptors in learning and memory

SO Ögren, TM Eriksson, E Elvander-Tottie… - Behavioural brain …, 2008 - Elsevier
The ascending serotonin (5-HT) neurons innervate the cerebral cortex, hippocampus,
septum and amygdala, all representing brain regions associated with various domains of …

Target site occupancy: emerging generalizations from clinical and preclinical studies

S Grimwood, PR Hartig - Pharmacology & therapeutics, 2009 - Elsevier
What percentage of receptors, ion channels or transporters must be occupied by drugs to
trigger therapeutic effects in patients, or by drugs and other ligands to induce physiological …

Effect of a polyphenol-rich wild blueberry extract on cognitive performance of mice, brain antioxidant markers and acetylcholinesterase activity

MA Papandreou, A Dimakopoulou, ZI Linardaki… - Behavioural brain …, 2009 - Elsevier
The aim of this study was to examine the effect of a polyphenol-rich extract (PrB) of
Vaccinium angustifolium (wild blueberries) introduced intraperitonealy (ip) at 30 (PrB30) and …

Memory enhancing effects of saffron in aged mice are correlated with antioxidant protection

MA Papandreou, M Tsachaki, S Efthimiopoulos… - Behavioural brain …, 2011 - Elsevier
Brain aging is characterized by cognitive decline and memory deficits that could be the
result of oxidative stress and impaired cholinergic function. In this study, the effects of a daily …

Investigation of the neuroprotective action of saffron (Crocus sativus L.) in aluminum-exposed adult mice through behavioral and neurobiochemical assessment

ZI Linardaki, MG Orkoula, AG Kokkosis… - Food and Chemical …, 2013 - Elsevier
In the present study, the possible reversal effects of saffron against established aluminum
(Al)-toxicity in adult mice, were investigated. Control, Al-treated (50mg AlCl3/kg/day diluted …

Rosemary tea consumption results to anxiolytic-and anti-depressant-like behavior of adult male mice and inhibits all cerebral area and liver cholinesterase activity; …

AV Ferlemi, A Katsikoudi, VG Kontogianni… - Chemico-biological …, 2015 - Elsevier
Our aim was to investigate the possible effects of regular drinking of Rosmarinus officinalis
L. leaf infusion on behavior and on AChE activity of mice. Rosemary tea (2% w/w) …

Analysis of the role of 5-HT1A receptors in spatial and aversive learning in the rat

M Lüttgen, E Elvander, N Madjid, SO Ögren - Neuropharmacology, 2005 - Elsevier
The role of the brain 5-HT1A receptor in cognition was examined in the water maze (WM)
and passive avoidance (PA) tasks in the male rat. Pre-training administration of the 5-HT1A …

Erythropoietin prevents cognition impairment induced by transient brain ischemia in gerbils

MA Catania, MC Marciano, A Parisi, A Sturiale… - European journal of …, 2002 - Elsevier
Erythropoietin has recently been studied for its role in the central nervous system (CNS). It
has been shown to exert neuroprotective effects in different models of brain injury. We …

5-HT1A and 5-HT7 receptor crosstalk in the regulation of emotional memory: implications for effects of selective serotonin reuptake inhibitors

TM Eriksson, S Holst, TL Stan, T Hager, B Sjögren… - …, 2012 - Elsevier
This study utilized pharmacological manipulations to analyze the role of direct and indirect
activation of 5-HT7 receptors (5-HT7Rs) in passive avoidance learning by assessing …

Saffron (Crocus sativus L.) Tea Intake Prevents Learning/Memory Defects and Neurobiochemical Alterations Induced by Aflatoxin B1 Exposure in Adult Mice

ZI Linardaki, FN Lamari, M Margarity - Neurochemical research, 2017 - Springer
This study aimed to investigate the potential neurotoxic effects of aflatoxin B 1 (AFB 1) and
the preventive effects of saffron. Male Balb-c mice received AFB 1 (0.6 mg/kg/day …