Analysis of cell‐free DNA in maternal blood in screening for fetal aneuploidies: updated meta‐analysis

MM Gil, MS Quezada, R Revello… - … in obstetrics & …, 2015 - Wiley Online Library
Objective To review clinical validation or implementation studies of maternal blood cell‐free
(cf) DNA analysis and define the performance of screening for fetal trisomies 21, 18 and 13 …

Screening for fetal aneuploidies at 11 to 13 weeks

KH Nicolaides - Prenatal diagnosis, 2011 - Wiley Online Library
Effective screening for major aneuploidies can be provided in the first trimester of
pregnancy. Screening by a combination of fetal nuchal translucency and maternal serum …

Competing risks model in early screening for preeclampsia by biophysical and biochemical markers

R Akolekar, A Syngelaki, L Poon, D Wright… - Fetal diagnosis and …, 2013 - karger.com
Objective: To develop models for prediction of preeclampsia (PE) based on maternal
characteristics, biophysical and biochemical markers at 11–13 weeks' gestation in which the …

Noninvasive prenatal testing for fetal trisomies in a routinely screened first-trimester population

KH Nicolaides, A Syngelaki, G Ashoor, C Birdir… - American journal of …, 2012 - Elsevier
OBJECTIVE: We sought to assess performance of noninvasive prenatal testing for fetal
trisomy in a routinely screened first-trimester pregnancy population. STUDY DESIGN: This …

Chromosome-selective sequencing of maternal plasma cell–free DNA for first-trimester detection of trisomy 21 and trisomy 18

G Ashoor, A Syngelaki, M Wagner, C Birdir… - American journal of …, 2012 - Elsevier
OBJECTIVE: The purpose of this study was to assess the prenatal detection rate of trisomy
21 and 18 and the false-positive rate by chromosome-selective sequencing of maternal …

A competing risks model in early screening for preeclampsia

D Wright, R Akolekar, A Syngelaki, LCY Poon… - Fetal diagnosis and …, 2012 - karger.com
Objective: It was the aim of this study to develop models for the prediction of preeclampsia
(PE) based on maternal characteristics and biophysical markers at 11–13 weeks' gestation …

Biochemical markers to predict preeclampsia

UD Anderson, MG Olsson, KH Kristensen, B Åkerström… - Placenta, 2012 - Elsevier
Worldwide the prevalence of preeclampsia (PE) ranges from 3 to 8% of pregnancies. 8.5
million cases are reported yearly, but this is probably an underestimate due to the lack of …

Protocol for measurement of mean arterial pressure at 11-13 weeks' gestation

LCY Poon, NA Zymeri, A Zamprakou… - Fetal diagnosis and …, 2012 - karger.com
Objectives: To identify the best protocol for measurement of mean arterial pressure (MAP) in
early pregnancy for the prediction of preeclampsia (PE). Methods: This was a prospective …

Combined screening for preeclampsia and small for gestational age at 11–13 weeks

LCY Poon, A Syngelaki, R Akolekar, J Lai… - Fetal diagnosis and …, 2013 - karger.com
Objective: To combine a specific algorithm for small for gestational age (SGA) without
preeclampsia (PE) and another algorithm for PE in the prediction of SGA and PE. Methods …

Towards deep phenotyping pregnancy: a systematic review on artificial intelligence and machine learning methods to improve pregnancy outcomes

L Davidson, MR Boland - Briefings in bioinformatics, 2021 - academic.oup.com
Objective Development of novel informatics methods focused on improving pregnancy
outcomes remains an active area of research. The purpose of this study is to systematically …