Neuropathy is the most common and debilitating complication of diabetes and results in
pain, decreased motility, and amputation. Diabetic neuropathy encompasses a variety of …

Nerve growth factor (NGF) was identified originally as a survival factor for sensory and
sympathetic neurons in the developing nervous system. In adults, NGF is not required for …

Spontaneous pain, a poorly understood aspect of human neuropathic pain, is indicated in
animals by spontaneous foot lifting (SFL). To determine whether SFL is caused by …

This review examines the fundamentals of neurogastroenterology that may underlie the
pathophysiology of functional GI disorders (FGIDs). It was prepared by an invited committee …

Binding to isolectin-B4 (IB4) and expression of tyrosine kinase A (trkA)(the high-affinity NGF
receptor) have been used to define two different subgroups of nociceptive small dorsal root …

Nerve growth factor (NGF) is the founding member of the neurotrophins family of proteins. It
was discovered more than half a century ago through its ability to promote sensory and …

Cutaneous mechanosensory neurons detect mechanical stimuli that generate touch and
pain sensation. Although opioids are generally associated only with the control of pain, here …

Intracellular recordings were made from 1022 somatic lumbar dorsal root ganglion (DRG)
neurones in anaesthetized adult rats, classified from dorsal root conduction velocities (CVs) …

Manipulation of neurotrophin (NT) signalling by administration or depletion of NTs, by
transgenic overexpression or by deletion of genes coding for NTs and their receptors has …

Abstract Treatment of neuropathic pain is a clinical challenge likely because of the time-
dependent changes in many neurotransmitter systems, growth factors, ionic channels …